Detailed information of TA system TA093754

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): BrnTA/BrnT-BrnA
• Location: 2862682..2863256
• Replicon: chromosome
• Accession: NZ_CP026265
• Organism: Aminobacter sp. MSH1

Toxin (Protein)

• Gene name: brnT
• Uniprot ID: -
• Locus tag: CO731_RS14115
• Protein ID: WP_108607656.1
• Coordinates: 2862993..2863256 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: brnA
• Uniprot ID: -
• Locus tag: CO731_RS14110
• Protein ID: WP_108607655.1
• Coordinates: 2862682..2862996 (-)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CO731_RS14100	2858126..2858581	+	456	WP_108607653.1	GNAT family N-acetyltransferase	-
CO731_RS14105	2858719..2862654	+	3936	WP_108607654.1	AsmA family protein	-
CO731_RS14110	2862682..2862996	-	315	WP_108607655.1	BrnA antitoxin family protein	Antitoxin
CO731_RS14115	2862993..2863256	-	264	WP_108607656.1	BrnT family toxin	Toxin
CO731_RS14120	2863346..2863582	-	237	WP_108607657.1	ribbon-helix-helix domain-containing protein	-
CO731_RS14125	2863579..2863776	-	198	WP_108607658.1	DUF4169 family protein	-
CO731_RS14130	2863795..2864334	-	540	WP_108607659.1	SspB family protein	-
CO731_RS14135	2864425..2865084	-	660	WP_108607660.1	TetR/AcrR family transcriptional regulator	-
CO731_RS14140	2865254..2866462	+	1209	WP_108607661.1	multidrug effflux MFS transporter	-
CO731_RS14145	2866658..2867800	+	1143	WP_159091640.1	GGDEF domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (5-82)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (25-101)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 9858.43 Da
• Isoelectric Point: 10.5537

>T93754 WP_108607656.1 NZ_CP026265:c2863256-2862993 [Aminobacter sp. MSH1]
MKIVWDEPKRLANLEKHGFDFADVVFFGWESAVIKPARPDNAGRRRMKAIGYFDNRVAVVIFTTLGTEAMSVISFRPASA
QERKVLS

Nucleotide

• Length: 264 bp

>T93754 NZ_CP026265:c2863256-2862993 [Aminobacter sp. MSH1]
ATGAAGATCGTCTGGGACGAACCAAAGCGTCTGGCCAATCTCGAAAAGCACGGCTTCGACTTCGCTGACGTAGTGTTTTT
CGGCTGGGAGTCTGCTGTCATCAAACCTGCCCGGCCAGACAACGCCGGTCGTCGACGAATGAAGGCAATCGGCTACTTCG
ACAATCGGGTCGCCGTGGTGATCTTCACCACACTGGGCACGGAAGCGATGTCCGTCATCAGCTTCAGGCCAGCAAGCGCT
CAGGAAAGGAAGGTTCTGTCATGA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 11649.25 Da
• Isoelectric Point: 8.5537

>AT93754 WP_108607655.1 NZ_CP026265:c2862996-2862682 [Aminobacter sp. MSH1]
MTGKTLKKAFEPGHGYTKEDWDAVDSPELTEEELAQFRPAQEVLPPEFFQGIEEARRARGRPSVEAPKQVVSIRLDPDVI
AKFKATGKGWQSRINDVLKKAKVG

Nucleotide

• Length: 315 bp

>AT93754 NZ_CP026265:c2862996-2862682 [Aminobacter sp. MSH1]
ATGACCGGCAAGACACTGAAAAAGGCGTTCGAACCTGGACACGGCTACACCAAGGAAGATTGGGATGCCGTGGACAGCCC
GGAACTGACTGAGGAAGAACTGGCCCAATTTCGCCCGGCTCAGGAAGTCTTGCCGCCAGAATTCTTCCAAGGCATCGAAG
AAGCACGCCGCGCTCGTGGCCGCCCCTCAGTCGAGGCGCCCAAGCAGGTCGTCTCGATTCGCCTCGATCCCGATGTCATC
GCCAAGTTCAAGGCCACCGGCAAAGGCTGGCAAAGCCGTATCAACGACGTCCTGAAAAAGGCCAAGGTCGGCTGA