Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1117283..1117889 Replicon chromosome
Accession NZ_CP026265
Organism Aminobacter sp. MSH1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag CO731_RS05480 Protein ID WP_108606293.1
Coordinates 1117283..1117471 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag CO731_RS05485 Protein ID WP_108606294.1
Coordinates 1117473..1117889 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CO731_RS28980 1113439..1113777 - 339 WP_199914563.1 hypothetical protein -
CO731_RS05460 1113997..1114476 + 480 WP_108609644.1 DUF2867 domain-containing protein -
CO731_RS05465 1114473..1115543 - 1071 WP_108606291.1 TraB/GumN family protein -
CO731_RS05470 1115614..1116552 - 939 WP_108606292.1 tyrosine recombinase XerC -
CO731_RS05475 1116621..1117223 + 603 WP_108609645.1 ribosome maturation factor RimM -
CO731_RS05480 1117283..1117471 + 189 WP_108606293.1 type II toxin-antitoxin system HicA family toxin Toxin
CO731_RS05485 1117473..1117889 + 417 WP_108606294.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CO731_RS05490 1117954..1118607 + 654 WP_108609646.1 tRNA (guanosine(37)-N1)-methyltransferase TrmD -
CO731_RS05495 1118744..1119112 - 369 Protein_1085 XRE family transcriptional regulator -
CO731_RS05500 1119112..1119408 - 297 WP_108606295.1 type II toxin-antitoxin system HigB family toxin -
CO731_RS05505 1119483..1120238 - 756 WP_108606296.1 sulfite exporter TauE/SafE family protein -
CO731_RS05510 1120583..1121131 + 549 WP_108606297.1 50S ribosomal protein L19 -
CO731_RS05515 1121312..1122109 + 798 WP_108609647.1 basic amino acid ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1115614..1119408 3794


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-124)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7004.18 Da        Isoelectric Point: 11.6500

>T93752 WP_108606293.1 NZ_CP026265:1117283-1117471 [Aminobacter sp. MSH1]
MRSREVIRLLVADGWVEVARKGSHVQFKHPSKKGRVTVPDPKSDIPQGTLRSIEKQSGIRLK

Download         Length: 189 bp

>T93752 NZ_CP026265:1117283-1117471 [Aminobacter sp. MSH1]
ATGCGCAGCCGTGAGGTAATCAGACTGCTTGTTGCCGACGGTTGGGTGGAAGTTGCGCGCAAGGGCAGCCACGTCCAGTT
CAAGCATCCGTCGAAAAAGGGCCGGGTCACGGTGCCGGACCCCAAGAGCGACATTCCACAAGGCACCCTGCGCAGCATCG
AAAAGCAATCCGGGATCAGGCTGAAATAG

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 14982.84 Da        Isoelectric Point: 4.3461

>AT93752 WP_108606294.1 NZ_CP026265:1117473-1117889 [Aminobacter sp. MSH1]
MANYIALIHKDADSDYGVSFPDFPGCVSAGPTLDEARAGAEEALALHMEGMLEDGEPIPEPTLLEDVMAVADNRDGVAVL
VKAPALDQRSIRVNVTFPEDVLKQIDQFAQQSGYTRSGFLAVAAKHEIEREEKRKARG

Download         Length: 417 bp

>AT93752 NZ_CP026265:1117473-1117889 [Aminobacter sp. MSH1]
ATGGCCAATTACATCGCCCTCATCCACAAGGACGCCGATAGCGACTATGGCGTGTCCTTCCCCGATTTTCCCGGCTGCGT
TTCGGCGGGTCCCACTCTCGACGAGGCGCGTGCCGGCGCCGAAGAGGCATTGGCACTGCATATGGAGGGAATGCTGGAGG
ATGGAGAGCCTATCCCTGAACCGACTTTGCTCGAAGATGTGATGGCGGTTGCCGACAATCGAGATGGCGTCGCCGTGTTG
GTCAAGGCGCCGGCGCTGGACCAGCGCTCCATCAGGGTCAATGTCACTTTCCCGGAGGACGTGCTGAAGCAGATCGACCA
GTTTGCCCAGCAGTCCGGCTATACGCGCTCGGGCTTCCTTGCGGTGGCCGCGAAGCACGAGATCGAGCGGGAAGAAAAGC
GAAAGGCGCGTGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References