Detailed information of TA system TA093752

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1117283..1117889
• Replicon: chromosome
• Accession: NZ_CP026265
• Organism: Aminobacter sp. MSH1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: CO731_RS05480
• Protein ID: WP_108606293.1
• Coordinates: 1117283..1117471 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: CO731_RS05485
• Protein ID: WP_108606294.1
• Coordinates: 1117473..1117889 (+)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CO731_RS28980	1113439..1113777	-	339	WP_199914563.1	hypothetical protein	-
CO731_RS05460	1113997..1114476	+	480	WP_108609644.1	DUF2867 domain-containing protein	-
CO731_RS05465	1114473..1115543	-	1071	WP_108606291.1	TraB/GumN family protein	-
CO731_RS05470	1115614..1116552	-	939	WP_108606292.1	tyrosine recombinase XerC	-
CO731_RS05475	1116621..1117223	+	603	WP_108609645.1	ribosome maturation factor RimM	-
CO731_RS05480	1117283..1117471	+	189	WP_108606293.1	type II toxin-antitoxin system HicA family toxin	Toxin
CO731_RS05485	1117473..1117889	+	417	WP_108606294.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
CO731_RS05490	1117954..1118607	+	654	WP_108609646.1	tRNA (guanosine(37)-N1)-methyltransferase TrmD	-
CO731_RS05495	1118744..1119112	-	369	Protein_1085	XRE family transcriptional regulator	-
CO731_RS05500	1119112..1119408	-	297	WP_108606295.1	type II toxin-antitoxin system HigB family toxin	-
CO731_RS05505	1119483..1120238	-	756	WP_108606296.1	sulfite exporter TauE/SafE family protein	-
CO731_RS05510	1120583..1121131	+	549	WP_108606297.1	50S ribosomal protein L19	-
CO731_RS05515	1121312..1122109	+	798	WP_108609647.1	basic amino acid ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1115614..1119408	3794

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-124)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7004.18 Da
• Isoelectric Point: 11.6500

>T93752 WP_108606293.1 NZ_CP026265:1117283-1117471 [Aminobacter sp. MSH1]
MRSREVIRLLVADGWVEVARKGSHVQFKHPSKKGRVTVPDPKSDIPQGTLRSIEKQSGIRLK

Nucleotide

• Length: 189 bp

>T93752 NZ_CP026265:1117283-1117471 [Aminobacter sp. MSH1]
ATGCGCAGCCGTGAGGTAATCAGACTGCTTGTTGCCGACGGTTGGGTGGAAGTTGCGCGCAAGGGCAGCCACGTCCAGTT
CAAGCATCCGTCGAAAAAGGGCCGGGTCACGGTGCCGGACCCCAAGAGCGACATTCCACAAGGCACCCTGCGCAGCATCG
AAAAGCAATCCGGGATCAGGCTGAAATAG

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 14982.84 Da
• Isoelectric Point: 4.3461

>AT93752 WP_108606294.1 NZ_CP026265:1117473-1117889 [Aminobacter sp. MSH1]
MANYIALIHKDADSDYGVSFPDFPGCVSAGPTLDEARAGAEEALALHMEGMLEDGEPIPEPTLLEDVMAVADNRDGVAVL
VKAPALDQRSIRVNVTFPEDVLKQIDQFAQQSGYTRSGFLAVAAKHEIEREEKRKARG

Nucleotide

• Length: 417 bp

>AT93752 NZ_CP026265:1117473-1117889 [Aminobacter sp. MSH1]
ATGGCCAATTACATCGCCCTCATCCACAAGGACGCCGATAGCGACTATGGCGTGTCCTTCCCCGATTTTCCCGGCTGCGT
TTCGGCGGGTCCCACTCTCGACGAGGCGCGTGCCGGCGCCGAAGAGGCATTGGCACTGCATATGGAGGGAATGCTGGAGG
ATGGAGAGCCTATCCCTGAACCGACTTTGCTCGAAGATGTGATGGCGGTTGCCGACAATCGAGATGGCGTCGCCGTGTTG
GTCAAGGCGCCGGCGCTGGACCAGCGCTCCATCAGGGTCAATGTCACTTTCCCGGAGGACGTGCTGAAGCAGATCGACCA
GTTTGCCCAGCAGTCCGGCTATACGCGCTCGGGCTTCCTTGCGGTGGCCGCGAAGCACGAGATCGAGCGGGAAGAAAAGC
GAAAGGCGCGTGGCTGA