93748

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-YefM
Location 72958..73529 Replicon plasmid pCFR-9161
Accession NZ_CP026237
Organism Citrobacter freundii complex sp. CFNIH3

Toxin (Protein)


Gene name parE Uniprot ID A0A2I8S8S5
Locus tag C2U38_RS27555 Protein ID WP_011918375.1
Coordinates 73218..73529 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1Z3MW28
Locus tag C2U38_RS27550 Protein ID WP_011787805.1
Coordinates 72958..73218 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2U38_RS27515 68369..68542 - 174 Protein_77 DUF1330 domain-containing protein -
C2U38_RS27520 68578..69042 - 465 Protein_78 Tn3 family transposase -
C2U38_RS27525 69310..70314 - 1005 WP_000427623.1 IS110-like element IS4321 family transposase -
C2U38_RS27530 70382..71722 - 1341 Protein_80 Tn3-like element Tn5403 family transposase -
C2U38_RS27535 71776..72480 - 705 WP_001067855.1 IS6-like element IS26 family transposase -
C2U38_RS27550 72958..73218 + 261 WP_011787805.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
C2U38_RS27555 73218..73529 + 312 WP_011918375.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C2U38_RS27560 73553..76633 + 3081 WP_011787830.1 Tn3 family transposase -
C2U38_RS27565 76688..76975 - 288 Protein_85 type II toxin-antitoxin system toxin endoribonuclease PemK -
C2U38_RS28570 76908..77165 - 258 WP_000557619.1 type II toxin-antitoxin system antitoxin PemI -
C2U38_RS27570 77258..77911 - 654 WP_000616807.1 CPBP family intramembrane metalloprotease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..235027 235027


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-61)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11862.70 Da        Isoelectric Point: 8.5341

>T93748 WP_011918375.1 NZ_CP026237:73218-73529 [Citrobacter freundii complex sp. CFNIH3]
MPVTYHLTPDAQSDLIGIHRFTLAQWGTTQSKTYLSGLRQTIQLLAETPTLGKNRPEVRMNVFSFPYSSHVIYYIQHEHQ
FVVFGILHKSMVPLAHLAEREII

Download         Length: 312 bp

>T93748 NZ_CP026237:73218-73529 [Citrobacter freundii complex sp. CFNIH3]
ATGCCGGTAACTTATCATTTAACGCCCGATGCACAATCTGATCTGATAGGTATTCACCGCTTTACGTTAGCCCAATGGGG
AACGACTCAGTCGAAGACCTATTTATCAGGACTTAGACAAACGATTCAACTGCTGGCTGAAACACCCACCCTTGGGAAAA
ATAGACCCGAGGTACGCATGAATGTGTTTAGCTTCCCTTATTCAAGTCATGTCATCTATTACATCCAACATGAGCATCAA
TTCGTTGTATTTGGGATCTTACATAAAAGTATGGTTCCACTTGCACATCTCGCGGAGCGGGAAATTATTTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9312.71 Da        Isoelectric Point: 6.4546

>AT93748 WP_011787805.1 NZ_CP026237:72958-73218 [Citrobacter freundii complex sp. CFNIH3]
MNTLSANEAKIHFGDLLLKAQQAPIQINKNGKPVAVVISADAYQSIETLKLHLLQSKAVKAITDIKMGNLVDGNTFFDEL
AAGQYD

Download         Length: 261 bp

>AT93748 NZ_CP026237:72958-73218 [Citrobacter freundii complex sp. CFNIH3]
ATGAACACTCTTTCAGCCAATGAAGCAAAAATTCACTTTGGAGATTTGTTGCTCAAAGCTCAACAAGCTCCAATCCAAAT
TAATAAAAATGGCAAGCCTGTGGCCGTTGTTATTTCAGCTGATGCATACCAAAGTATCGAGACACTAAAATTACATTTGC
TTCAATCCAAAGCGGTGAAAGCCATAACTGACATCAAAATGGGCAATTTGGTTGATGGTAATACCTTTTTTGATGAGCTG
GCCGCAGGGCAGTATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I8S8S5

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z3MW28

References