93746

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4389268..4390021 Replicon chromosome
Accession NZ_CP026235
Organism Citrobacter freundii complex sp. CFNIH3

Toxin (Protein)


Gene name yeeV Uniprot ID A0A097QYR4
Locus tag C2U38_RS22030 Protein ID WP_025799003.1
Coordinates 4389268..4389645 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A7T0E0C6
Locus tag C2U38_RS22035 Protein ID WP_072269511.1
Coordinates 4389695..4390021 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2U38_RS22000 4384921..4386765 + 1845 WP_016154549.1 RNA polymerase sigma factor RpoD -
C2U38_RS22005 4386811..4387317 - 507 WP_103284247.1 G/U mismatch-specific DNA glycosylase -
C2U38_RS22015 4387621..4388466 - 846 WP_025799009.1 DUF4942 domain-containing protein -
C2U38_RS22020 4388548..4388751 - 204 WP_025799007.1 DUF957 domain-containing protein -
C2U38_RS22025 4388780..4389271 - 492 WP_045888216.1 hypothetical protein -
C2U38_RS22030 4389268..4389645 - 378 WP_025799003.1 TA system toxin CbtA family protein Toxin
C2U38_RS22035 4389695..4390021 - 327 WP_072269511.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
C2U38_RS22040 4390078..4390299 - 222 WP_045888217.1 DUF987 domain-containing protein -
C2U38_RS22045 4390313..4390792 - 480 WP_025798999.1 DNA repair protein RadC -
C2U38_RS22050 4390804..4391235 - 432 WP_088903392.1 antirestriction protein -
C2U38_RS22055 4391458..4394928 - 3471 WP_103284248.1 AIDA repeat-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(4-103)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13993.97 Da        Isoelectric Point: 6.8515

>T93746 WP_025799003.1 NZ_CP026235:c4389645-4389268 [Citrobacter freundii complex sp. CFNIH3]
MQTQPVPPTQEASPRPSPVEIWLRLLSHLLDRHYGLTLNDTPFCNDGVIQEHIDAGISLCDAVNFIVEKYALIRTDRHGF
SAETQSPLISSIDILRARKACGLMARNGYRLVTDITTGKYSEVTR

Download         Length: 378 bp

>T93746 NZ_CP026235:c4389645-4389268 [Citrobacter freundii complex sp. CFNIH3]
ATGCAAACACAACCTGTTCCCCCGACACAGGAGGCTTCACCACGCCCGTCACCAGTGGAGATCTGGCTCCGCCTTTTGAG
TCACCTGCTGGACCGTCACTACGGTCTGACGTTAAACGACACGCCATTTTGCAATGATGGTGTGATCCAGGAGCATATCG
ACGCCGGTATCTCACTGTGCGACGCGGTGAATTTTATCGTGGAGAAATACGCCCTGATACGCACCGATCGTCACGGTTTC
AGCGCAGAAACACAGTCCCCACTCATCAGCAGTATTGATATCCTTCGCGCCCGTAAGGCCTGTGGACTGATGGCACGCAA
TGGCTACAGACTGGTGACCGATATCACCACCGGCAAATACAGCGAGGTGACTCGATGA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12016.71 Da        Isoelectric Point: 6.4674

>AT93746 WP_072269511.1 NZ_CP026235:c4390021-4389695 [Citrobacter freundii complex sp. CFNIH3]
IAEPWWGLKRDITPCFGARLVQEGNRLHYLADRASITGQFSDADLRHLDQAFPLLLKQLELMLTSGELNPRHQHGVTLYA
KGLTCNADTLGSCGYVYIAIYPTPATTE

Download         Length: 327 bp

>AT93746 NZ_CP026235:c4390021-4389695 [Citrobacter freundii complex sp. CFNIH3]
ATCGCCGAACCCTGGTGGGGGCTTAAACGCGATATCACACCCTGTTTTGGCGCTCGCCTGGTGCAGGAGGGCAACCGGCT
GCACTATCTCGCCGACCGCGCCAGTATCACCGGGCAGTTCAGCGACGCGGATTTACGCCATCTGGACCAGGCATTTCCGC
TGCTGCTCAAACAGCTTGAACTGATGCTCACCAGCGGTGAACTCAATCCCCGCCATCAGCACGGCGTCACGCTCTACGCA
AAAGGGCTGACCTGCAACGCGGATACACTCGGCAGTTGCGGATATGTCTATATAGCGATTTACCCGACACCTGCAACAAC
AGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A097QYR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7T0E0C6

References