93735

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-YefM
Location 2459650..2460221 Replicon chromosome
Accession NZ_CP026235
Organism Citrobacter freundii complex sp. CFNIH3

Toxin (Protein)


Gene name parE Uniprot ID A0A2I8S8S5
Locus tag C2U38_RS12270 Protein ID WP_011918375.1
Coordinates 2459650..2459961 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1Z3MW28
Locus tag C2U38_RS12275 Protein ID WP_011787805.1
Coordinates 2459961..2460221 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2U38_RS12260 2455502..2456491 + 990 Protein_2300 efflux MFS transporter YdeE -
C2U38_RS12265 2456546..2459626 - 3081 WP_011787830.1 Tn3 family transposase -
C2U38_RS12270 2459650..2459961 - 312 WP_011918375.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C2U38_RS12275 2459961..2460221 - 261 WP_011787805.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
C2U38_RS12280 2460391..2461011 + 621 WP_011787804.1 recombinase family protein -
C2U38_RS12285 2461129..2461461 - 333 WP_011787803.1 TraR/DksA C4-type zinc finger protein -
C2U38_RS12290 2461552..2462406 - 855 WP_011787802.1 universal stress protein -
C2U38_RS12295 2462441..2463931 - 1491 WP_011787801.1 SulP family inorganic anion transporter -
C2U38_RS12300 2464430..2464630 + 201 Protein_2308 efflux MFS transporter YdeE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-61)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11862.70 Da        Isoelectric Point: 8.5341

>T93735 WP_011918375.1 NZ_CP026235:c2459961-2459650 [Citrobacter freundii complex sp. CFNIH3]
MPVTYHLTPDAQSDLIGIHRFTLAQWGTTQSKTYLSGLRQTIQLLAETPTLGKNRPEVRMNVFSFPYSSHVIYYIQHEHQ
FVVFGILHKSMVPLAHLAEREII

Download         Length: 312 bp

>T93735 NZ_CP026235:c2459961-2459650 [Citrobacter freundii complex sp. CFNIH3]
ATGCCGGTAACTTATCATTTAACGCCCGATGCACAATCTGATCTGATAGGTATTCACCGCTTTACGTTAGCCCAATGGGG
AACGACTCAGTCGAAGACCTATTTATCAGGACTTAGACAAACGATTCAACTGCTGGCTGAAACACCCACCCTTGGGAAAA
ATAGACCCGAGGTACGCATGAATGTGTTTAGCTTCCCTTATTCAAGTCATGTCATCTATTACATCCAACATGAGCATCAA
TTCGTTGTATTTGGGATCTTACATAAAAGTATGGTTCCACTTGCACATCTCGCGGAGCGGGAAATTATTTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9312.71 Da        Isoelectric Point: 6.4546

>AT93735 WP_011787805.1 NZ_CP026235:c2460221-2459961 [Citrobacter freundii complex sp. CFNIH3]
MNTLSANEAKIHFGDLLLKAQQAPIQINKNGKPVAVVISADAYQSIETLKLHLLQSKAVKAITDIKMGNLVDGNTFFDEL
AAGQYD

Download         Length: 261 bp

>AT93735 NZ_CP026235:c2460221-2459961 [Citrobacter freundii complex sp. CFNIH3]
ATGAACACTCTTTCAGCCAATGAAGCAAAAATTCACTTTGGAGATTTGTTGCTCAAAGCTCAACAAGCTCCAATCCAAAT
TAATAAAAATGGCAAGCCTGTGGCCGTTGTTATTTCAGCTGATGCATACCAAAGTATCGAGACACTAAAATTACATTTGC
TTCAATCCAAAGCGGTGAAAGCCATAACTGACATCAAAATGGGCAATTTGGTTGATGGTAATACCTTTTTTGATGAGCTG
GCCGCAGGGCAGTATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I8S8S5

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z3MW28

References