Detailed information of TA system TA093732

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeV-yfjZ/CbtA-CbeA
• Location: 1313847..1314570
• Replicon: chromosome
• Accession: NZ_CP026235
• Organism: Citrobacter freundii complex sp. CFNIH3

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: C2U38_RS06550
• Protein ID: WP_103283577.1
• Coordinates: 1313847..1314167 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: C2U38_RS06555
• Protein ID: WP_103283578.1
• Coordinates: 1314235..1314570 (-)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C2U38_RS06520	1308862..1309251	+	390	WP_065805889.1	TA system toxin CbtA family protein	-
C2U38_RS06525	1309338..1310183	+	846	WP_065805890.1	DUF4942 domain-containing protein	-
C2U38_RS06535	1311086..1312138	-	1053	WP_103283575.1	macro domain-containing protein	-
C2U38_RS06540	1312152..1312799	-	648	WP_103284449.1	DUF4433 domain-containing protein	-
C2U38_RS06545	1312900..1313733	-	834	WP_103283576.1	DUF4942 domain-containing protein	-
C2U38_RS06550	1313847..1314167	-	321	WP_103283577.1	TA system toxin CbtA family protein	Toxin
C2U38_RS06555	1314235..1314570	-	336	WP_103283578.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
C2U38_RS06560	1314587..1314808	-	222	WP_103283579.1	DUF987 domain-containing protein	-
C2U38_RS06565	1314818..1315297	-	480	WP_103283580.1	DNA repair protein RadC	-
C2U38_RS06570	1315309..1315773	-	465	WP_103283581.1	antirestriction protein	-
C2U38_RS06575	1315963..1316712	-	750	Protein_1233	autotransporter domain-containing protein	-
C2U38_RS06580	1316693..1316782	-	90	Protein_1234	transcriptional regulator	-
C2U38_RS06590	1317017..1317838	-	822	WP_103283583.1	DUF945 domain-containing protein	-
C2U38_RS06595	1317930..1318793	-	864	WP_103283584.1	GTPase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1284829..1374117	89288

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (13-105)

Antitoxin

• Antitoxin CbeA (8-106)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12020.70 Da
• Isoelectric Point: 5.5094

>T93732 WP_103283577.1 NZ_CP026235:c1314167-1313847 [Citrobacter freundii complex sp. CFNIH3]
MQISTAPATVPVLSRLSPVQVWQQLLTYLLEHHYGLTLNDTPFHDDAAIMEHIEAGVTLADAVNFLVERYELVRTDRKGF
TWQEQTPFLTATDILRARRATGLINT

Nucleotide

• Length: 321 bp

>T93732 NZ_CP026235:c1314167-1313847 [Citrobacter freundii complex sp. CFNIH3]
ATGCAAATCTCAACTGCACCGGCCACGGTGCCGGTTTTGTCACGTCTGTCGCCCGTGCAGGTCTGGCAGCAATTGTTAAC
GTATCTTTTAGAGCACCATTACGGCCTCACACTAAACGACACACCATTCCATGACGATGCAGCAATCATGGAGCATATTG
AAGCGGGAGTAACGCTGGCTGATGCGGTGAATTTCCTGGTGGAACGCTATGAGCTGGTGCGTACTGACCGCAAAGGGTTT
ACATGGCAGGAGCAGACGCCATTCCTGACCGCTACCGATATTCTCAGAGCAAGGCGAGCTACCGGATTAATAAATACTTA
A

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12616.32 Da
• Isoelectric Point: 6.2047

>AT93732 WP_103283578.1 NZ_CP026235:c1314570-1314235 [Citrobacter freundii complex sp. CFNIH3]
MHNNDATEWGLRRDITPRFGARLVQEGHRLHFLADRAGFTGMFSEVQALQLDEAFPHFVAHLELMLLSCELNPRCAHCVT
LYRNGLTCEADTLGSYGYVYIAIYPSNQVKD

Nucleotide

• Length: 336 bp

>AT93732 NZ_CP026235:c1314570-1314235 [Citrobacter freundii complex sp. CFNIH3]
ATGCACAACAATGATGCCACCGAATGGGGGCTTCGACGGGATATCACACCACGATTTGGCGCAAGGCTGGTGCAGGAAGG
TCATCGTCTGCATTTTCTGGCGGACCGGGCAGGATTCACCGGTATGTTCAGTGAGGTACAGGCCCTACAACTGGATGAAG
CCTTCCCTCATTTTGTCGCACATCTGGAGCTGATGCTGCTCTCCTGTGAGCTGAATCCCCGGTGCGCGCACTGCGTCACG
CTGTACCGTAACGGGTTGACCTGTGAAGCCGATACGCTGGGCAGTTATGGGTATGTGTATATCGCAATTTATCCCTCAAA
TCAGGTTAAAGACTAA