Detailed information of TA system TA093731

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 1308479..1309251
• Replicon: chromosome
• Accession: NZ_CP026235
• Organism: Citrobacter freundii complex sp. CFNIH3

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: A0A2I8S4E2
• Locus tag: C2U38_RS06520
• Protein ID: WP_065805889.1
• Coordinates: 1308862..1309251 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: C2U38_RS06515
• Protein ID: WP_175364756.1
• Coordinates: 1308479..1308805 (+)
• Length: 109 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1284829..1374117	89288

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-111)

Antitoxin

• Antitoxin CbeA (4-103)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 14321.40 Da
• Isoelectric Point: 9.9883

>T93731 WP_065805889.1 NZ_CP026235:1308862-1309251 [Citrobacter freundii complex sp. CFNIH3]
MQTKSSPLMRAASSRPSPVSVWQTLLTSLLAQHYGLTLSDTPFSDEQVIQQHIDAGISLVDALNFIVEKYELVRTDRPGF
SILTQSPFITPIDILRARKATGLMNRDTYKEVTAITRGQHPQVSAPGKR

Nucleotide

• Length: 390 bp

>T93731 NZ_CP026235:1308862-1309251 [Citrobacter freundii complex sp. CFNIH3]
ATGCAAACCAAATCATCCCCCCTCATGCGGGCGGCATCGTCACGTCCGTCTCCGGTGAGTGTCTGGCAGACCCTGCTGAC
CAGCCTGCTGGCACAACACTATGGCCTCACGCTTAGCGATACGCCGTTCAGTGATGAACAGGTCATTCAGCAACATATTG
ATGCCGGTATCTCGCTGGTTGATGCCCTGAATTTTATCGTTGAGAAGTATGAACTGGTCCGCACTGACCGCCCAGGCTTC
AGCATCCTGACGCAGTCTCCGTTTATCACACCCATAGATATCCTCCGGGCCAGGAAAGCAACGGGGCTGATGAACCGTGA
CACGTATAAAGAGGTGACGGCTATTACCAGAGGGCAACATCCGCAGGTCAGCGCTCCAGGCAAGCGATGA

Antitoxin

Protein

• Length: 109 a.a.
• Molecular weight: 12054.78 Da
• Isoelectric Point: 6.9459

>AT93731 WP_175364756.1 NZ_CP026235:1308479-1308805 [Citrobacter freundii complex sp. CFNIH3]
ISEPWWGLRRSVSPCFGARLVQEGNRLHYLADRANVSGQFCDADLRHLDQAFPILLKQLELMLTSGELNPRHQHCVTLYA
KGLTCEADTLGSHGYVYIAIYPTPVATA

Nucleotide

• Length: 327 bp

>AT93731 NZ_CP026235:1308479-1308805 [Citrobacter freundii complex sp. CFNIH3]
ATCAGCGAACCCTGGTGGGGGCTCAGGCGAAGTGTCTCCCCGTGTTTTGGGGCCCGTCTGGTCCAGGAGGGAAACCGCCT
GCATTACCTGGCTGACCGGGCGAATGTTAGCGGACAGTTCTGTGATGCGGATTTACGCCATCTTGACCAGGCTTTCCCGA
TATTGCTCAAACAGCTGGAGTTAATGCTCACCAGCGGTGAACTGAATCCCCGTCATCAGCACTGCGTCACGCTGTATGCA
AAAGGTCTGACCTGCGAGGCCGATACGCTCGGTTCGCACGGCTATGTTTATATCGCGATTTATCCCACTCCTGTCGCCAC
GGCATAA

Structures

Toxin

• AlphaFold DB: A0A2I8S4E2