93729

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yafW-ykfI/CbtA-CbeA
Location 983867..984546 Replicon chromosome
Accession NZ_CP026235
Organism Citrobacter freundii complex sp. CFNIH3

Toxin (Protein)


Gene name ykfI Uniprot ID A0A2I8S2T2
Locus tag C2U38_RS04855 Protein ID WP_008324514.1
Coordinates 983867..984208 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yafW Uniprot ID A0A2I8S2U6
Locus tag C2U38_RS04860 Protein ID WP_008324516.1
Coordinates 984229..984546 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2U38_RS04830 979097..979570 + 474 WP_016155774.1 hypothetical protein -
C2U38_RS04835 979913..981361 + 1449 WP_103283510.1 EAL domain-containing protein -
C2U38_RS04840 981555..982019 + 465 WP_103283511.1 isoprenylcysteine carboxylmethyltransferase family protein -
C2U38_RS04855 983867..984208 - 342 WP_008324514.1 type IV toxin-antitoxin system toxin YkfI Toxin
C2U38_RS04860 984229..984546 - 318 WP_008324516.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
C2U38_RS04865 984559..984786 - 228 WP_008324517.1 DUF987 domain-containing protein -
C2U38_RS04870 984795..985271 - 477 WP_000811693.1 RadC family protein -
C2U38_RS04875 985287..985745 - 459 WP_000211838.1 antirestriction protein -
C2U38_RS04880 985843..986082 - 240 WP_000194654.1 DUF905 domain-containing protein -
C2U38_RS04885 986159..986626 - 468 WP_001547765.1 hypothetical protein -
C2U38_RS04890 986649..987092 - 444 WP_000824223.1 hypothetical protein -
C2U38_RS04895 987092..987328 - 237 WP_001115854.1 hypothetical protein -
C2U38_RS04900 987365..988066 - 702 WP_008324530.1 WYL domain-containing protein -
C2U38_RS04905 988284..989105 - 822 WP_032654809.1 DUF945 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(6-104)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12919.98 Da        Isoelectric Point: 9.6543

>T93729 WP_008324514.1 NZ_CP026235:c984208-983867 [Citrobacter freundii complex sp. CFNIH3]
MKTLPATTQRAAKPCLSPVAVWQMLLTRLLEQHYGLTINDTPFCNEAVIKEHIDAGITLADAVNFLVEKYELVRIDRKGF
NWQEQSPYLRAVDILRARQATGLLRQSRNNVVR

Download         Length: 342 bp

>T93729 NZ_CP026235:c984208-983867 [Citrobacter freundii complex sp. CFNIH3]
ATGAAAACTTTACCTGCAACAACTCAGCGGGCGGCGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTGGAAAAATACGAACTGGTGCGTATCGACAGGAAGGGATTT
AACTGGCAGGAACAATCCCCTTATCTCCGGGCTGTAGACATTCTGCGAGCACGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11787.33 Da        Isoelectric Point: 7.3476

>AT93729 WP_008324516.1 NZ_CP026235:c984546-984229 [Citrobacter freundii complex sp. CFNIH3]
MSNPTRGLQRAITPRLGARLVQEGNRLHYLADRASITGRFSDTECRKLDETCPHFIRHMESMLTTGELSPQHAHCVTLYH
NGFTCEADTLGSCGYVYIAIYPTQS

Download         Length: 318 bp

>AT93729 NZ_CP026235:c984546-984229 [Citrobacter freundii complex sp. CFNIH3]
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGCTATCACGCCGCGCCTGGGAGCCCGTCTGGTGCAGGAGGGTAACCGACT
GCACTATCTGGCTGACAGGGCCAGCATCACCGGCAGGTTCAGTGACACCGAATGCCGGAAGCTGGATGAAACATGCCCGC
ACTTTATCCGCCATATGGAGTCGATGCTAACCACCGGTGAACTCAGTCCCCAACACGCCCACTGCGTCACCCTGTACCAC
AACGGTTTCACCTGCGAAGCCGATACTCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGAGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I8S2T2

Antitoxin

Source ID Structure
AlphaFold DB A0A2I8S2U6

References