Detailed information of TA system TA093726

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 460651..461170
• Replicon: chromosome
• Accession: NZ_CP026235
• Organism: Citrobacter freundii complex sp. CFNIH3

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: C2U38_RS02370
• Protein ID: WP_019078244.1
• Coordinates: 460889..461170 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: C2U38_RS02365
• Protein ID: WP_103283421.1
• Coordinates: 460651..460899 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C2U38_RS02350	456401..457348	+	948	WP_103284439.1	type VI secretion system baseplate subunit TssG	-
C2U38_RS02355	457339..459840	+	2502	WP_103283420.1	type VI secretion system ATPase TssH	-
C2U38_RS02360	459883..460356	+	474	WP_016155556.1	hypothetical protein	-
C2U38_RS02365	460651..460899	+	249	WP_103283421.1	plasmid stabilization protein	Antitoxin
C2U38_RS02370	460889..461170	+	282	WP_019078244.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
C2U38_RS02375	461198..463162	+	1965	WP_103283422.1	type VI secretion system tip protein VgrG	-
C2U38_RS02380	463162..463683	+	522	WP_049270665.1	hypothetical protein	-
C2U38_RS02385	463705..464169	-	465	WP_016151476.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10988.76 Da
• Isoelectric Point: 10.4466

>T93726 WP_019078244.1 NZ_CP026235:460889-461170 [Citrobacter freundii complex sp. CFNIH3]
MTYNLEFLDIALKEWRKLSPALREQFKKKLAERLENPHVPAARLSGKLHRYKIKLRSAGYRLVYQVEDEQVVVLVIAVGR
RDGDEVYHQANRR

Nucleotide

• Length: 282 bp

>T93726 NZ_CP026235:460889-461170 [Citrobacter freundii complex sp. CFNIH3]
ATGACCTATAACCTGGAGTTTTTAGATATTGCGCTCAAGGAGTGGCGCAAGCTTTCCCCTGCATTACGCGAGCAGTTCAA
AAAGAAACTGGCGGAGCGGCTGGAAAATCCCCATGTCCCTGCCGCCCGCCTTTCCGGCAAATTACACCGTTACAAAATCA
AGCTTCGCAGTGCCGGGTATCGTCTGGTCTATCAGGTCGAGGACGAGCAGGTTGTCGTTCTTGTGATCGCAGTGGGCAGA
CGTGATGGTGATGAGGTTTATCATCAGGCTAACCGGCGCTAG

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9073.37 Da
• Isoelectric Point: 4.5680

>AT93726 WP_103283421.1 NZ_CP026235:460651-460899 [Citrobacter freundii complex sp. CFNIH3]
MPFHILTKTAASITDLKRNPMGTVNAGEGEAVAILNRNEPAFYCVPPAVYAYLLELVEDAELNRIADEREDGKRIKVSLN
DL

Nucleotide

• Length: 249 bp

>AT93726 NZ_CP026235:460651-460899 [Citrobacter freundii complex sp. CFNIH3]
ATGCCATTTCATATCCTGACCAAAACCGCTGCCAGTATCACCGACCTGAAACGTAACCCAATGGGGACAGTCAACGCCGG
GGAGGGTGAAGCGGTGGCGATTCTGAACCGCAATGAGCCAGCGTTTTACTGCGTGCCGCCTGCGGTTTATGCGTATCTGC
TGGAGCTGGTAGAAGACGCCGAGCTGAACCGTATCGCCGACGAACGTGAAGATGGAAAGCGAATAAAGGTGTCTTTAAAT
GACCTATAA