Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 911..1430 Replicon plasmid pAER-cc3e
Accession NZ_CP026229
Organism Aeromonas sp. ASNIH1

Toxin (Protein)


Gene name relE Uniprot ID A0A2L0U0N7
Locus tag C2U37_RS23950 Protein ID WP_068979439.1
Coordinates 911..1198 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2L0U081
Locus tag C2U37_RS23955 Protein ID WP_068979438.1
Coordinates 1188..1430 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2U37_RS23950 911..1198 - 288 WP_068979439.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C2U37_RS23955 1188..1430 - 243 WP_068979438.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
C2U37_RS23960 1609..2238 + 630 WP_068979437.1 AAA family ATPase -
C2U37_RS23965 2235..2468 + 234 WP_068979436.1 hypothetical protein -
C2U37_RS23970 2527..5493 - 2967 WP_104452934.1 Tn3 family transposase -
C2U37_RS23975 5497..6057 - 561 WP_033958617.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..17473 17473


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(2-62)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11370.15 Da        Isoelectric Point: 9.7908

>T93725 WP_068979439.1 NZ_CP026229:c1198-911 [Aeromonas sp. ASNIH1]
MTFELEFDPRAWKEWKKLGDTVRQQFKKKLSEVIERPRIEANRLNGMSDCYKIKLRGAGYRLVYQVQDDRVVVFVVAVGR
REREEVYLDAMSRLD

Download         Length: 288 bp

>T93725 NZ_CP026229:c1198-911 [Aeromonas sp. ASNIH1]
ATGACCTTTGAACTCGAGTTTGATCCGCGAGCGTGGAAAGAGTGGAAAAAGTTGGGCGATACCGTTCGCCAGCAGTTCAA
AAAGAAACTTTCAGAGGTGATCGAGCGCCCCAGGATTGAGGCAAACAGGCTGAATGGGATGTCTGATTGCTACAAGATCA
AATTGCGTGGCGCGGGGTATCGGTTGGTTTACCAGGTACAGGATGATCGGGTGGTGGTATTCGTGGTCGCAGTGGGGAGG
CGCGAACGGGAAGAGGTATATCTGGATGCCATGTCACGTCTTGATTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8871.16 Da        Isoelectric Point: 4.7571

>AT93725 WP_068979438.1 NZ_CP026229:c1430-1188 [Aeromonas sp. ASNIH1]
MGTINLRIDDELKARSFAVLDKLGVTPSDIIRQTLEYVASQGRSPFRTTVVTEDEEALLAIVRERLASPQKGIKVSLDDL

Download         Length: 243 bp

>AT93725 NZ_CP026229:c1430-1188 [Aeromonas sp. ASNIH1]
ATGGGCACGATTAACCTGCGCATTGATGATGAACTGAAGGCACGTTCATTTGCGGTGCTGGACAAATTGGGGGTGACCCC
CTCGGATATTATCCGGCAAACCCTGGAGTATGTGGCCTCTCAGGGGCGGAGCCCGTTTCGCACTACCGTGGTGACGGAGG
ACGAAGAGGCACTGTTAGCCATCGTGCGAGAGCGCTTGGCCAGCCCGCAGAAAGGCATCAAGGTATCGCTGGATGACCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2L0U0N7

Antitoxin

Source ID Structure
AlphaFold DB A0A2L0U081

References