Detailed information of TA system TA093724

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 4380387..4381951
• Replicon: chromosome
• Accession: NZ_CP026228
• Organism: Aeromonas sp. ASNIH1

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A2L0TXX7
• Locus tag: C2U37_RS21185
• Protein ID: WP_059169586.1
• Coordinates: 4380641..4381951 (+)
• Length: 437 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: C2U37_RS21180
• Protein ID: WP_005329233.1
• Coordinates: 4380387..4380641 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C2U37_RS21155	4375962..4376540	-	579	WP_021140685.1	hypothetical protein	-
C2U37_RS21160	4376872..4377324	-	453	WP_021140686.1	DUF2384 domain-containing protein	-
C2U37_RS21165	4377504..4378886	+	1383	WP_197060245.1	Fic family protein	-
C2U37_RS21170	4378965..4379216	+	252	WP_010674977.1	plasmid stabilization protein	-
C2U37_RS21175	4379637..4379885	-	249	WP_010674978.1	hypothetical protein	-
C2U37_RS21180	4380387..4380641	+	255	WP_005329233.1	helix-turn-helix domain-containing protein	Antitoxin
C2U37_RS21185	4380641..4381951	+	1311	WP_059169586.1	type II toxin-antitoxin system HipA family toxin	Toxin
C2U37_RS21200	4382907..4385081	+	2175	WP_104453007.1	catalase/peroxidase HPI	-
C2U37_RS21205	4385182..4385946	-	765	WP_104453008.1	DeoR/GlpR family DNA-binding transcription regulator	-
C2U37_RS24940	4385990..4386217	-	228	WP_199770477.1	HAD hydrolase family protein	-
C2U37_RS24945	4386227..4386619	-	393	WP_199770478.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-104)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 437 a.a.
• Molecular weight: 49136.32 Da
• Isoelectric Point: 7.1717

>T93724 WP_059169586.1 NZ_CP026228:4380641-4381951 [Aeromonas sp. ASNIH1]
MASLTVYMNGYRVGTFTKATNGAHQFQYDESWVKLPGSRPISLSMPLRQQRYQGDEAYNFFDNLLPDNPEVRNRVVARYQ
ADSTQPFDLLSCIGQDSVGALQLVAQGRPVPDVKRIECKPLSDAELEQILTSYQQGIPLGMVREEDDFRISIAGAQEKTA
LLYLDNRWCLPHAATPTTHIIKLPIGKIESHSYSIDLSQSVENEYLCTLIAKALGLPVPHCFIMQVGKVKALAVERFDRR
YATDRSWIMRLPQEDFCQVLNVPSARKYESHGGPGIADIMTTLLGSATPEQDRYLFMKSQVLFWLLAATDGHAKNFSVFI
EPEGRFRLTPFYDILSMYPAFGGKGLHPRDAKLAMGLTATKGKKYAIEQIFPRHFYQTAKTIGFEQVQMEKIISELTDNL
DEVISIVRQQLPDTFPTEIADSILGGLSSRAQRLKR

Nucleotide

• Length: 1311 bp

>T93724 NZ_CP026228:4380641-4381951 [Aeromonas sp. ASNIH1]
ATGGCCAGCCTGACGGTCTACATGAACGGATACCGGGTAGGTACCTTTACCAAGGCGACCAATGGTGCTCACCAATTTCA
GTACGATGAATCGTGGGTGAAGTTGCCAGGCAGCCGCCCCATCTCGCTCTCCATGCCATTACGCCAGCAGCGCTACCAGG
GCGATGAGGCCTATAACTTCTTCGATAATCTGCTGCCAGATAACCCGGAAGTAAGAAACCGGGTGGTGGCGCGCTATCAA
GCCGATTCCACCCAACCCTTTGATCTGCTCAGTTGCATTGGCCAGGACAGCGTGGGGGCATTGCAACTGGTGGCTCAGGG
CAGACCTGTGCCAGACGTTAAGCGCATTGAGTGCAAGCCGCTCTCTGACGCCGAACTGGAGCAGATCCTGACCAGCTACC
AGCAAGGGATCCCGCTTGGTATGGTGAGGGAAGAGGACGATTTTCGGATATCCATCGCCGGGGCTCAGGAAAAGACCGCG
TTACTCTACCTCGACAACCGTTGGTGCTTACCGCATGCAGCGACCCCAACCACCCACATTATCAAGCTGCCCATTGGCAA
GATCGAAAGCCACTCCTACTCGATAGACCTCTCCCAGAGCGTAGAAAACGAATATCTCTGCACCCTGATCGCCAAAGCAT
TGGGTCTTCCGGTTCCCCATTGCTTCATCATGCAGGTCGGCAAGGTCAAGGCTCTGGCGGTGGAACGCTTCGATCGGCGC
TACGCCACGGATCGCAGTTGGATCATGCGCCTGCCCCAAGAGGACTTCTGCCAGGTGTTGAATGTACCGTCAGCACGCAA
GTACGAGAGCCATGGTGGACCGGGCATTGCTGACATCATGACGACCCTGCTGGGATCGGCCACGCCGGAGCAGGATCGGT
ACCTGTTTATGAAGTCTCAGGTGTTGTTCTGGCTGCTGGCTGCCACTGATGGCCATGCCAAGAATTTCTCGGTGTTTATC
GAACCTGAAGGGCGTTTCCGGCTTACACCGTTTTACGACATCCTTTCCATGTATCCTGCATTTGGTGGTAAAGGATTACA
TCCCCGTGATGCCAAGTTGGCCATGGGGCTTACTGCAACCAAGGGCAAAAAATACGCGATAGAGCAGATATTTCCTCGCC
ATTTTTATCAAACGGCCAAGACGATTGGTTTTGAACAAGTGCAGATGGAAAAAATCATCAGCGAGCTGACGGATAATCTG
GATGAGGTAATATCAATCGTTCGTCAGCAATTGCCTGATACATTTCCCACTGAGATTGCAGATTCAATTTTGGGTGGACT
CAGTTCGAGAGCTCAACGCTTAAAACGATAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9271.66 Da
• Isoelectric Point: 9.1571

>AT93724 WP_005329233.1 NZ_CP026228:4380387-4380641 [Aeromonas sp. ASNIH1]
MKVTSAKQLSACLKDARLSQKLSQGKVAGKVGIRQDTVSSFELNPESTKLETLFKILAALELSLDIRPRTDPAENATPGW
KEEW

Nucleotide

• Length: 255 bp

>AT93724 NZ_CP026228:4380387-4380641 [Aeromonas sp. ASNIH1]
ATGAAAGTAACCAGCGCCAAGCAACTTAGTGCCTGTCTCAAGGATGCCAGGCTTTCGCAAAAGCTCTCCCAAGGCAAAGT
GGCCGGCAAGGTGGGGATCAGGCAGGACACGGTGTCCAGCTTCGAGCTCAATCCCGAGTCAACCAAGCTGGAGACCTTGT
TCAAGATCCTCGCCGCACTGGAACTCTCCCTCGATATCAGGCCCCGCACCGATCCTGCGGAAAACGCCACGCCTGGCTGG
AAGGAGGAGTGGTAA

Structures

Toxin

• AlphaFold DB: A0A2L0TXX7