Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 15167..15704 Replicon plasmid pAER-3367
Accession NZ_CP026223
Organism Aeromonas sp. ASNIH3

Toxin (Protein)


Gene name relE Uniprot ID A0A2L0X163
Locus tag C2U39_RS22705 Protein ID WP_060986098.1
Coordinates 15167..15448 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2L0X100
Locus tag C2U39_RS22710 Protein ID WP_060986097.1
Coordinates 15435..15704 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2U39_RS24380 10369..10575 - 207 WP_158657364.1 hypothetical protein -
C2U39_RS22675 10878..11894 - 1017 WP_099533763.1 replication protein -
C2U39_RS22680 11958..12227 - 270 WP_099533765.1 ribbon-helix-helix domain-containing protein -
C2U39_RS22685 12242..12901 - 660 WP_099533767.1 AAA family ATPase -
C2U39_RS22690 13024..13872 - 849 WP_099533769.1 recombinase family protein -
C2U39_RS22695 14009..14392 - 384 WP_031943200.1 hypothetical protein -
C2U39_RS22700 14389..14952 - 564 WP_058165502.1 recombinase family protein -
C2U39_RS22705 15167..15448 - 282 WP_060986098.1 type II toxin-antitoxin system YafQ family toxin Toxin
C2U39_RS22710 15435..15704 - 270 WP_060986097.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
C2U39_RS22715 16000..16212 + 213 WP_041855125.1 hypothetical protein -
C2U39_RS22720 16205..17353 + 1149 WP_099533773.1 DNA cytosine methyltransferase -
C2U39_RS22725 17353..18282 + 930 WP_099533775.1 DUF4928 family protein -
C2U39_RS24525 18279..18455 + 177 WP_188073945.1 hypothetical protein -
C2U39_RS22730 18452..18664 + 213 WP_099533777.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..18892 18892
- flank IS/Tn - - 14389..14952 563


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(8-82)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10657.05 Da        Isoelectric Point: 9.0398

>T93720 WP_060986098.1 NZ_CP026223:c15448-15167 [Aeromonas sp. ASNIH3]
MRTIDRSSAFKRDFKREAKGQHRATLDDALKPVLLALATDQPLDARHRDHDLSGDWAGYRECHIKPDLLLIYRKSDSDTL
RLARLGSHSELFG

Download         Length: 282 bp

>T93720 NZ_CP026223:c15448-15167 [Aeromonas sp. ASNIH3]
ATGCGGACGATTGATCGTTCGTCCGCGTTCAAGCGCGATTTCAAGCGCGAGGCCAAGGGACAGCACCGTGCCACGCTCGA
TGACGCGCTCAAGCCGGTGCTGCTCGCGCTGGCGACCGATCAGCCGTTGGACGCGCGCCACCGCGACCATGATCTTTCCG
GCGATTGGGCGGGCTACCGCGAGTGCCACATCAAGCCCGACCTGCTGCTGATTTACCGCAAGTCCGATTCCGACACTCTG
CGACTGGCGCGGCTTGGCTCGCATAGCGAGCTTTTCGGCTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9688.09 Da        Isoelectric Point: 6.4667

>AT93720 WP_060986097.1 NZ_CP026223:c15704-15435 [Aeromonas sp. ASNIH3]
MSTTADTYVRARIDTNTKERAASALEAMGLSISDAIRLLMLRIADEHRLPFDVKVPNATTKKAIAELEAGKGKKFASVDN
LMADLHADD

Download         Length: 270 bp

>AT93720 NZ_CP026223:c15704-15435 [Aeromonas sp. ASNIH3]
ATGAGCACTACAGCCGACACCTACGTCCGCGCCCGCATCGACACCAACACCAAGGAACGCGCCGCCAGCGCACTCGAAGC
AATGGGCTTGTCGATTTCCGACGCCATCCGCCTGTTGATGCTGCGCATCGCCGATGAGCACCGCTTGCCTTTTGACGTGA
AGGTGCCCAACGCCACGACCAAAAAGGCGATTGCCGAACTGGAAGCGGGCAAGGGCAAGAAGTTCGCCAGCGTGGACAAC
CTAATGGCAGACCTGCATGCGGACGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2L0X163

Antitoxin

Source ID Structure
AlphaFold DB A0A2L0X100

References