Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 23791..24359 Replicon plasmid pKPC-ac48
Accession NZ_CP026219
Organism Aeromonas sp. ASNIH4

Toxin (Protein)


Gene name parE Uniprot ID A0A0D0R3P1
Locus tag C2U40_RS24880 Protein ID WP_011222050.1
Coordinates 24066..24359 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A3S7DUI6
Locus tag C2U40_RS24875 Protein ID WP_043849769.1
Coordinates 23791..24078 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2U40_RS24840 18944..19231 + 288 WP_068979439.1 type II toxin-antitoxin system RelE/ParE family toxin -
C2U40_RS24845 19414..20412 + 999 WP_068979440.1 replication initiation protein -
C2U40_RS24850 20567..20857 - 291 WP_042650710.1 hypothetical protein -
C2U40_RS24855 21066..21479 + 414 WP_043849774.1 plasmid mobilization relaxosome protein MobC -
C2U40_RS24860 21469..23085 + 1617 WP_082044045.1 relaxase/mobilization nuclease domain-containing protein -
C2U40_RS24865 23123..23410 + 288 WP_043849770.1 hypothetical protein -
C2U40_RS24875 23791..24078 + 288 WP_043849769.1 CopG family ribbon-helix-helix protein Antitoxin
C2U40_RS24880 24066..24359 + 294 WP_011222050.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C2U40_RS24885 24374..24904 + 531 WP_043849768.1 hypothetical protein -
C2U40_RS24890 25015..25140 + 126 Protein_34 type II toxin-antitoxin system CcdA family antitoxin -
C2U40_RS24895 25188..26117 - 930 WP_003150544.1 recombinase family protein -
C2U40_RS24900 26319..26558 + 240 WP_003089107.1 ribbon-helix-helix domain-containing protein -
C2U40_RS24905 26558..26968 + 411 WP_003150546.1 putative toxin-antitoxin system toxin component, PIN family -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid blaKPC-2 - 1..35298 35298


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-94)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-45)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10890.71 Da        Isoelectric Point: 10.8518

>T93718 WP_011222050.1 NZ_CP026219:24066-24359 [Aeromonas sp. ASNIH4]
MPQVILSPAALRDLKRLREFLHSKSPVVAQRAAQTIRSALAQLGQQPAMGRPIEGLPEVFREWVIPFGDSGYLARYRLEG
ETVVILALRHQREAGFI

Download         Length: 294 bp

>T93718 NZ_CP026219:24066-24359 [Aeromonas sp. ASNIH4]
ATGCCACAAGTGATCCTCTCTCCGGCTGCTCTGCGTGACCTTAAACGGCTGCGCGAGTTCTTGCACAGTAAGAGCCCGGT
TGTTGCACAGCGAGCAGCCCAAACCATCCGTTCGGCGCTGGCCCAGCTCGGGCAACAACCCGCGATGGGGCGTCCTATTG
AAGGGCTCCCGGAGGTGTTCCGCGAGTGGGTTATCCCCTTTGGGGACAGTGGTTATCTGGCGCGTTACCGCCTAGAGGGC
GAAACCGTAGTGATCTTGGCTCTGCGTCACCAGCGCGAAGCCGGGTTTATTTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10892.16 Da        Isoelectric Point: 5.1897

>AT93718 WP_043849769.1 NZ_CP026219:23791-24078 [Aeromonas sp. ASNIH4]
MSAATKPMSIKLDSDTQSRIKQLAAARDRSAHWMMREAITQYVEREERKEAFRRDTLDAWQEFQETGLHVSLEEADQWLA
GWGTEIEGGAPACHK

Download         Length: 288 bp

>AT93718 NZ_CP026219:23791-24078 [Aeromonas sp. ASNIH4]
ATGTCCGCAGCTACCAAACCCATGTCTATCAAACTTGATAGCGATACCCAAAGCCGGATCAAGCAGCTAGCTGCTGCCCG
CGACCGTTCAGCGCACTGGATGATGCGCGAAGCTATCACCCAGTATGTTGAGCGCGAAGAGCGCAAGGAGGCGTTCCGCC
GCGATACCCTCGATGCTTGGCAGGAGTTTCAGGAGACTGGTTTGCATGTCTCTCTTGAGGAGGCCGATCAGTGGTTGGCT
GGTTGGGGCACCGAGATTGAAGGTGGTGCACCTGCATGCCACAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D0R3P1

Antitoxin

Source ID Structure
AlphaFold DB A0A3S7DUI6

References