Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relB-parE/ParE-RHH |
Location | 23791..24359 | Replicon | plasmid pKPC-ac48 |
Accession | NZ_CP026219 | ||
Organism | Aeromonas sp. ASNIH4 |
Toxin (Protein)
Gene name | parE | Uniprot ID | A0A0D0R3P1 |
Locus tag | C2U40_RS24880 | Protein ID | WP_011222050.1 |
Coordinates | 24066..24359 (+) | Length | 98 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | A0A3S7DUI6 |
Locus tag | C2U40_RS24875 | Protein ID | WP_043849769.1 |
Coordinates | 23791..24078 (+) | Length | 96 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
C2U40_RS24840 | 18944..19231 | + | 288 | WP_068979439.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
C2U40_RS24845 | 19414..20412 | + | 999 | WP_068979440.1 | replication initiation protein | - |
C2U40_RS24850 | 20567..20857 | - | 291 | WP_042650710.1 | hypothetical protein | - |
C2U40_RS24855 | 21066..21479 | + | 414 | WP_043849774.1 | plasmid mobilization relaxosome protein MobC | - |
C2U40_RS24860 | 21469..23085 | + | 1617 | WP_082044045.1 | relaxase/mobilization nuclease domain-containing protein | - |
C2U40_RS24865 | 23123..23410 | + | 288 | WP_043849770.1 | hypothetical protein | - |
C2U40_RS24875 | 23791..24078 | + | 288 | WP_043849769.1 | CopG family ribbon-helix-helix protein | Antitoxin |
C2U40_RS24880 | 24066..24359 | + | 294 | WP_011222050.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
C2U40_RS24885 | 24374..24904 | + | 531 | WP_043849768.1 | hypothetical protein | - |
C2U40_RS24890 | 25015..25140 | + | 126 | Protein_34 | type II toxin-antitoxin system CcdA family antitoxin | - |
C2U40_RS24895 | 25188..26117 | - | 930 | WP_003150544.1 | recombinase family protein | - |
C2U40_RS24900 | 26319..26558 | + | 240 | WP_003089107.1 | ribbon-helix-helix domain-containing protein | - |
C2U40_RS24905 | 26558..26968 | + | 411 | WP_003150546.1 | putative toxin-antitoxin system toxin component, PIN family | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Mobilizable plasmid | blaKPC-2 | - | 1..35298 | 35298 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 98 a.a. Molecular weight: 10890.71 Da Isoelectric Point: 10.8518
>T93718 WP_011222050.1 NZ_CP026219:24066-24359 [Aeromonas sp. ASNIH4]
MPQVILSPAALRDLKRLREFLHSKSPVVAQRAAQTIRSALAQLGQQPAMGRPIEGLPEVFREWVIPFGDSGYLARYRLEG
ETVVILALRHQREAGFI
MPQVILSPAALRDLKRLREFLHSKSPVVAQRAAQTIRSALAQLGQQPAMGRPIEGLPEVFREWVIPFGDSGYLARYRLEG
ETVVILALRHQREAGFI
Download Length: 294 bp
>T93718 NZ_CP026219:24066-24359 [Aeromonas sp. ASNIH4]
ATGCCACAAGTGATCCTCTCTCCGGCTGCTCTGCGTGACCTTAAACGGCTGCGCGAGTTCTTGCACAGTAAGAGCCCGGT
TGTTGCACAGCGAGCAGCCCAAACCATCCGTTCGGCGCTGGCCCAGCTCGGGCAACAACCCGCGATGGGGCGTCCTATTG
AAGGGCTCCCGGAGGTGTTCCGCGAGTGGGTTATCCCCTTTGGGGACAGTGGTTATCTGGCGCGTTACCGCCTAGAGGGC
GAAACCGTAGTGATCTTGGCTCTGCGTCACCAGCGCGAAGCCGGGTTTATTTAG
ATGCCACAAGTGATCCTCTCTCCGGCTGCTCTGCGTGACCTTAAACGGCTGCGCGAGTTCTTGCACAGTAAGAGCCCGGT
TGTTGCACAGCGAGCAGCCCAAACCATCCGTTCGGCGCTGGCCCAGCTCGGGCAACAACCCGCGATGGGGCGTCCTATTG
AAGGGCTCCCGGAGGTGTTCCGCGAGTGGGTTATCCCCTTTGGGGACAGTGGTTATCTGGCGCGTTACCGCCTAGAGGGC
GAAACCGTAGTGATCTTGGCTCTGCGTCACCAGCGCGAAGCCGGGTTTATTTAG
Antitoxin
Download Length: 96 a.a. Molecular weight: 10892.16 Da Isoelectric Point: 5.1897
>AT93718 WP_043849769.1 NZ_CP026219:23791-24078 [Aeromonas sp. ASNIH4]
MSAATKPMSIKLDSDTQSRIKQLAAARDRSAHWMMREAITQYVEREERKEAFRRDTLDAWQEFQETGLHVSLEEADQWLA
GWGTEIEGGAPACHK
MSAATKPMSIKLDSDTQSRIKQLAAARDRSAHWMMREAITQYVEREERKEAFRRDTLDAWQEFQETGLHVSLEEADQWLA
GWGTEIEGGAPACHK
Download Length: 288 bp
>AT93718 NZ_CP026219:23791-24078 [Aeromonas sp. ASNIH4]
ATGTCCGCAGCTACCAAACCCATGTCTATCAAACTTGATAGCGATACCCAAAGCCGGATCAAGCAGCTAGCTGCTGCCCG
CGACCGTTCAGCGCACTGGATGATGCGCGAAGCTATCACCCAGTATGTTGAGCGCGAAGAGCGCAAGGAGGCGTTCCGCC
GCGATACCCTCGATGCTTGGCAGGAGTTTCAGGAGACTGGTTTGCATGTCTCTCTTGAGGAGGCCGATCAGTGGTTGGCT
GGTTGGGGCACCGAGATTGAAGGTGGTGCACCTGCATGCCACAAGTGA
ATGTCCGCAGCTACCAAACCCATGTCTATCAAACTTGATAGCGATACCCAAAGCCGGATCAAGCAGCTAGCTGCTGCCCG
CGACCGTTCAGCGCACTGGATGATGCGCGAAGCTATCACCCAGTATGTTGAGCGCGAAGAGCGCAAGGAGGCGTTCCGCC
GCGATACCCTCGATGCTTGGCAGGAGTTTCAGGAGACTGGTTTGCATGTCTCTCTTGAGGAGGCCGATCAGTGGTTGGCT
GGTTGGGGCACCGAGATTGAAGGTGGTGCACCTGCATGCCACAAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0D0R3P1 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3S7DUI6 |