Detailed information of TA system TA093716

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 4867088..4868661
• Replicon: chromosome
• Accession: NZ_CP026217
• Organism: Aeromonas sp. ASNIH4

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: C2U40_RS22805
• Protein ID: WP_103828286.1
• Coordinates: 4867088..4868407 (-)
• Length: 440 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A3Q8DTG9
• Locus tag: C2U40_RS22810
• Protein ID: WP_042047685.1
• Coordinates: 4868407..4868661 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C2U40_RS22790	4862766..4863650	+	885	WP_181014861.1	ABC transporter substrate-binding protein	-
C2U40_RS22795	4863647..4865629	+	1983	WP_103828285.1	Fe(3+)-hydroxamate ABC transporter permease FhuB	-
C2U40_RS22800	4865753..4866713	+	961	Protein_4395	IS1595 family transposase	-
C2U40_RS22805	4867088..4868407	-	1320	WP_103828286.1	type II toxin-antitoxin system HipA family toxin	Toxin
C2U40_RS22810	4868407..4868661	-	255	WP_042047685.1	helix-turn-helix domain-containing protein	Antitoxin
C2U40_RS22815	4869199..4869822	+	624	WP_103828287.1	recombinase family protein	-
C2U40_RS22825	4870655..4871626	+	972	Protein_4399	transposase	-
C2U40_RS26310	4871814..4872263	+	450	WP_146054395.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	4865753..4866673	920

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-104)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 440 a.a.
• Molecular weight: 49529.48 Da
• Isoelectric Point: 6.5038

>T93716 WP_103828286.1 NZ_CP026217:c4868407-4867088 [Aeromonas sp. ASNIH4]
MANLAVYMNGYRVGTFTKTTSGAHQFQYHESWLAQSGSRPISLSMPLRHQAYRGDEAYNFFDNLLPDNTEVRNRVVARYQ
AASTQPFDLLSCIGQDSVGALQLVTEGHDVPDVRRIDYKALSDDELEQILTSYKSGIPLGMVREQEEFRISIAGAQEKTA
LLYLDDRWYLPLNATPTTHIIKLPIGKIESHSYSIDLSQSVENEYLCTLIAKEFGLPVPHCFMMQVGQVKALAVERFDRR
YAADRSWIMRLPQEDFCQVLNVPSARKYENHGGPGITDIMKTLLGSATPEQDRYLLMKSQVLFWLLAATDGHAKNFSVFI
EPEGRFRLTPFYDILSVYPVFGGRGLNQRDAKLAMGLASSKGKKYAIEQIFPRHFFQTAKAVGFERSAMEEILTELANSV
DDVIERVTQQLPAGFPDTISSTILEGLKARSARLIKCWD

Nucleotide

• Length: 1320 bp

>T93716 NZ_CP026217:c4868407-4867088 [Aeromonas sp. ASNIH4]
ATGGCCAATCTGGCTGTCTACATGAACGGCTATCGGGTAGGCACATTCACCAAAACTACCAGCGGTGCCCATCAGTTTCA
GTACCATGAATCATGGCTAGCACAATCGGGTAGCCGTCCGATCTCACTCTCCATGCCATTGCGCCATCAGGCCTACCGAG
GCGATGAAGCCTATAACTTCTTCGACAACCTGCTGCCAGATAATACAGAGGTGAGGAACAGGGTTGTAGCACGCTATCAA
GCGGCATCAACCCAGCCCTTCGATCTGCTCAGTTGCATTGGCCAGGATAGCGTAGGGGCATTACAGCTGGTTACCGAAGG
GCACGACGTTCCAGATGTCAGGCGAATCGACTACAAAGCACTTTCCGATGACGAGCTCGAGCAGATCCTGACCAGCTACA
AATCAGGAATCCCTTTGGGGATGGTCAGAGAGCAAGAGGAGTTCCGGATCTCTATCGCCGGGGCGCAAGAAAAGACTGCG
CTGCTCTATCTCGATGACCGTTGGTACTTGCCACTCAACGCAACGCCGACAACCCACATTATCAAACTCCCTATCGGCAA
GATTGAAAGCCACTCCTACTCGATAGACCTCTCCCAGAGCGTAGAAAACGAATATCTCTGCACTCTGATTGCCAAGGAGT
TTGGTCTACCCGTACCTCACTGCTTCATGATGCAGGTTGGCCAGGTCAAAGCACTGGCTGTGGAGCGCTTCGACAGACGT
TACGCTGCCGATCGCAGTTGGATCATGCGCCTTCCCCAAGAAGATTTCTGTCAGGTATTGAATGTTCCGTCAGCACGGAA
ATACGAGAACCATGGAGGACCGGGGATCACTGACATCATGAAAACCTTGCTGGGCTCTGCGACACCAGAACAGGATCGCT
ACCTGTTAATGAAATCTCAGGTCCTGTTCTGGCTGCTGGCGGCCACCGATGGCCATGCAAAAAACTTCTCGGTCTTTATT
GAGCCGGAAGGGCGTTTTCGCCTGACCCCTTTTTACGACATCCTATCTGTCTATCCAGTGTTTGGCGGCCGAGGCCTCAA
CCAAAGGGACGCCAAGCTCGCTATGGGCCTAGCAAGCAGCAAGGGAAAGAAGTACGCCATTGAGCAGATATTCCCGCGTC
ATTTCTTCCAAACGGCGAAAGCTGTGGGATTTGAGCGTTCTGCTATGGAAGAGATCCTGACAGAACTGGCCAACTCCGTT
GATGATGTTATTGAGCGCGTTACACAGCAATTGCCAGCAGGCTTCCCCGATACCATCAGCAGCACAATTCTAGAGGGCCT
AAAAGCCCGCTCAGCCAGGCTGATAAAGTGCTGGGATTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9293.62 Da
• Isoelectric Point: 7.9834

>AT93716 WP_042047685.1 NZ_CP026217:c4868661-4868407 [Aeromonas sp. ASNIH4]
MKVTSAKQLSACIKDARLSQKLSQGKVAEKVGIRQDTVSSFELNPESTKLETLFKILAALELSLDIKPRNESSDSPASGW
KEEW

Nucleotide

• Length: 255 bp

>AT93716 NZ_CP026217:c4868661-4868407 [Aeromonas sp. ASNIH4]
ATGAAAGTAACCAGCGCCAAGCAGCTGAGCGCCTGTATCAAGGATGCCAGGCTTTCTCAAAAGCTCTCTCAAGGCAAAGT
GGCCGAGAAAGTGGGGATTAGGCAAGACACAGTCTCCAGCTTCGAGCTCAATCCTGAGTCCACCAAGCTGGAAACCCTGT
TCAAGATCCTCGCGGCACTCGAATTGTCACTGGACATCAAACCCCGCAATGAGTCATCCGATAGTCCGGCATCGGGCTGG
AAGGAGGAGTGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A3Q8DTG9