Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 3865070..3865706 Replicon chromosome
Accession NZ_CP026216
Organism Citrobacter sp. CFNIH10

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag C2U53_RS22455 Protein ID WP_104446469.1
Coordinates 3865515..3865706 (-) Length 64 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag C2U53_RS22450 Protein ID WP_172740616.1
Coordinates 3865070..3865486 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2U53_RS22430 3860127..3861071 - 945 WP_104446466.1 ABC transporter permease -
C2U53_RS22435 3861072..3862085 - 1014 WP_104446467.1 ABC transporter ATP-binding protein -
C2U53_RS22440 3862103..3863248 - 1146 WP_090050444.1 ABC transporter substrate-binding protein -
C2U53_RS22445 3863573..3864982 - 1410 WP_099433027.1 PLP-dependent aminotransferase family protein -
C2U53_RS22450 3865070..3865486 - 417 WP_172740616.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
C2U53_RS22455 3865515..3865706 - 192 WP_104446469.1 type II toxin-antitoxin system HicA family toxin Toxin
C2U53_RS22460 3865972..3867375 + 1404 WP_104446470.1 cytochrome ubiquinol oxidase subunit I -
C2U53_RS22465 3867375..3868385 + 1011 WP_043000643.1 cytochrome d ubiquinol oxidase subunit II -
C2U53_RS22470 3868385..3868513 + 129 WP_071888398.1 DUF2474 domain-containing protein -
C2U53_RS22475 3868553..3870514 - 1962 WP_104446471.1 U32 family peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-65)


Sequences

Toxin        


Download         Length: 64 a.a.        Molecular weight: 7056.19 Da        Isoelectric Point: 11.3246

>T93703 WP_104446469.1 NZ_CP026216:c3865706-3865515 [Citrobacter sp. CFNIH10]
VKQSEFRRCLESQGAGVTNGSHHLKLRYRGKRSVMPRHPGDEIKEALRKAILKQLGLSSSSLI

Download         Length: 192 bp

>T93703 NZ_CP026216:c3865706-3865515 [Citrobacter sp. CFNIH10]
GTGAAGCAGAGCGAATTCCGACGCTGTCTGGAATCTCAGGGAGCCGGGGTAACGAATGGTTCGCACCATTTGAAGCTGAG
ATATCGCGGAAAACGCAGCGTCATGCCCAGACATCCGGGTGATGAGATCAAAGAGGCCTTGCGTAAAGCCATTCTGAAGC
AATTGGGCCTGTCGTCATCATCACTGATATGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15185.41 Da        Isoelectric Point: 4.9371

>AT93703 WP_172740616.1 NZ_CP026216:c3865486-3865070 [Citrobacter sp. CFNIH10]
MRYPVRLVPAPEGGYVVSFPDIPEALTQGETRQQSLDTALEALVTAFEFYFEDSQSVPLPSPVKEGDDFVEVPLSVASKV
LLLNAFLASKISQQELAKRIGRPKQEITRLFDLRHATKIDAVQTAARALGKELSLTLS

Download         Length: 417 bp

>AT93703 NZ_CP026216:c3865486-3865070 [Citrobacter sp. CFNIH10]
ATGCGCTATCCCGTTCGTCTCGTTCCTGCGCCAGAAGGTGGCTATGTGGTTTCGTTTCCGGATATTCCGGAAGCGCTCAC
CCAGGGTGAGACCCGCCAGCAATCCCTTGATACCGCTCTGGAAGCGTTAGTCACCGCTTTTGAATTCTATTTCGAAGATA
GCCAGTCTGTTCCGTTACCTTCGCCGGTGAAGGAAGGTGACGACTTTGTTGAGGTCCCGCTCAGCGTCGCGTCAAAAGTC
CTTTTGCTCAACGCTTTCCTGGCGTCAAAAATCAGCCAGCAGGAGCTGGCGAAACGCATTGGCAGACCGAAACAGGAAAT
TACCCGCCTGTTCGACTTACGACACGCAACAAAAATTGATGCGGTGCAGACGGCGGCGCGCGCGCTCGGCAAAGAACTGT
CGCTTACGCTGTCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References