Detailed information of TA system TA093701

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 3321763..3322582
• Replicon: chromosome
• Accession: NZ_CP026216
• Organism: Citrobacter sp. CFNIH10

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: A0A3S5G4N2
• Locus tag: C2U53_RS19680
• Protein ID: WP_043001077.1
• Coordinates: 3321763..3322020 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: C2U53_RS19685
• Protein ID: WP_044258114.1
• Coordinates: 3322031..3322582 (+)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C2U53_RS19650	3317569..3318474	-	906	WP_043001082.1	dihydrodipicolinate synthase family protein	-
C2U53_RS19655	3318479..3319267	-	789	WP_043001081.1	IclR family transcriptional regulator	-
C2U53_RS19660	3319503..3320294	+	792	WP_043001080.1	PhzF family phenazine biosynthesis protein	-
C2U53_RS19665	3320775..3321167	+	393	WP_043001079.1	VOC family protein	-
C2U53_RS19670	3321177..3321383	+	207	WP_043001078.1	tryptophan synthase subunit alpha	-
C2U53_RS19680	3321763..3322020	+	258	WP_043001077.1	YjhX family toxin	Toxin
C2U53_RS19685	3322031..3322582	+	552	WP_044258114.1	N-acetyltransferase	Antitoxin
C2U53_RS19690	3322634..3323380	+	747	WP_054177314.1	class I SAM-dependent methyltransferase	-
C2U53_RS19695	3324056..3324640	+	585	WP_044264020.1	hypothetical protein	-
C2U53_RS19700	3324951..3326075	-	1125	WP_104446326.1	N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9490.00 Da
• Isoelectric Point: 11.1381

>T93701 WP_043001077.1 NZ_CP026216:3321763-3322020 [Citrobacter sp. CFNIH10]
MNLSRQEQRTLHVLAKGGRIAHVRDASGRVTAVECYSREGLLLADCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QPDNR

Nucleotide

• Length: 258 bp

>T93701 NZ_CP026216:3321763-3322020 [Citrobacter sp. CFNIH10]
ATGAATTTATCCCGTCAGGAACAACGTACCTTACACGTTCTCGCCAAAGGTGGACGTATTGCGCACGTCCGCGATGCGTC
AGGCCGCGTCACCGCCGTTGAATGCTACAGCCGCGAAGGGCTGCTGCTCGCCGACTGTACACTTGCCGTCTTCAAAAAAC
TCAAAACCAAAAAGCTGATCAAATCCGTCAATGGTCAGCCGTACCGCATTAATACCACCGGGCTGAACAACGTGCGTGCT
CAGCCAGATAACCGCTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20365.25 Da
• Isoelectric Point: 6.0668

>AT93701 WP_044258114.1 NZ_CP026216:3322031-3322582 [Citrobacter sp. CFNIH10]
MTTRNFTIHITDESDTNDIREVETRAFGYSKEACLVASLLEDDTARPTLSLLARQEGNAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGRGVGGLLIRTGIEHLRSMGCQCVFVLGHATYYPRHGFEPCAGDKGFPAPYPIAEEHKACWMMQSLSA
QPFDRAGDIQCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT93701 NZ_CP026216:3322031-3322582 [Citrobacter sp. CFNIH10]
ATGACAACACGCAACTTCACTATTCATATTACCGATGAAAGTGATACCAACGACATCCGGGAAGTCGAAACCCGCGCCTT
TGGCTACAGTAAAGAGGCCTGCCTGGTGGCTTCTTTGCTCGAGGACGACACTGCGCGTCCAACGTTATCGTTGCTGGCCA
GACAGGAAGGTAACGCCGTCGGGCATATCCTGTTTACCCGGGCGACATTCAAAGGAGAAATGGATTCCCCTCTGATGCAT
ATCCTTGCTCCCCTGGCGGTCATCCCTGAATACCAGGGGAGGGGCGTGGGCGGATTATTGATTCGTACCGGTATAGAACA
CTTACGCTCGATGGGATGCCAGTGCGTTTTTGTTCTCGGTCATGCCACTTACTATCCGCGACATGGATTTGAACCCTGTG
CAGGAGACAAAGGCTTTCCCGCGCCTTACCCCATTGCGGAGGAACATAAGGCCTGCTGGATGATGCAGTCCCTCTCCGCA
CAACCCTTTGATCGTGCCGGCGACATCCAATGTGCGCAGGCCTTAATGAAACCGGAGCACTGGCGTGAATAA

Structures

Toxin

• AlphaFold DB: A0A3S5G4N2