Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2595843..2596463 Replicon chromosome
Accession NZ_CP026216
Organism Citrobacter sp. CFNIH10

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag C2U53_RS15950 Protein ID WP_001280991.1
Coordinates 2595843..2596061 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A3Q8DH98
Locus tag C2U53_RS15955 Protein ID WP_042324455.1
Coordinates 2596089..2596463 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2U53_RS15920 2591496..2592092 + 597 WP_104446100.1 hypothetical protein -
C2U53_RS15925 2592175..2592528 + 354 WP_043001561.1 DUF1428 family protein -
C2U53_RS15930 2592568..2594118 - 1551 WP_054176085.1 EAL domain-containing protein -
C2U53_RS15935 2594341..2594481 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
C2U53_RS15940 2594531..2595001 - 471 WP_043001559.1 YlaC family protein -
C2U53_RS15945 2595115..2595666 - 552 WP_104446101.1 maltose O-acetyltransferase -
C2U53_RS15950 2595843..2596061 - 219 WP_001280991.1 hemolysin expression modulator Hha Toxin
C2U53_RS15955 2596089..2596463 - 375 WP_042324455.1 Hha toxicity modulator TomB Antitoxin
C2U53_RS15960 2596975..2600124 - 3150 WP_043001557.1 multidrug efflux RND transporter permease subunit -
C2U53_RS15965 2600147..2601340 - 1194 WP_104446102.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T93699 WP_001280991.1 NZ_CP026216:c2596061-2595843 [Citrobacter sp. CFNIH10]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T93699 NZ_CP026216:c2596061-2595843 [Citrobacter sp. CFNIH10]
ATGTCCGATAAACCATTAACTAAAACTGATTATTTGATGCGCTTGCGACGCTGTCAGACAATTGACACACTTGAACGCGT
GATTGAGAAAAATAAATATGAATTATCTGACAATGAATTGGCTGTATTTTACTCAGCCGCCGATCACCGTCTTGCAGAAT
TGACGATGAATAAACTTTACGACAAGATCCCCTCCTCCGTCTGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14495.31 Da        Isoelectric Point: 4.8989

>AT93699 WP_042324455.1 NZ_CP026216:c2596463-2596089 [Citrobacter sp. CFNIH10]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT93699 NZ_CP026216:c2596463-2596089 [Citrobacter sp. CFNIH10]
ATGGATGAATACTCACCCAAAAGACATGATATAGCGCAGCTTAAATTTCTTTGTGAAACGCTTTATCACGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTTCAACTCAACGAACTGATAGAGC
ATATTGCAACCTTCGCACTTAATTATAAAATTAAGTATAATGAGGACAATAAGCTGATTGAGCAGATTGATGAATATCTG
GACGACACATTTATGTTGTTCAGCAGTTATGGCATTAATGCGCAGGATCTGCAGAAATGGCGGAAATCAGGTAATCGCTT
GTTCCGTTGCTTTGTGAATGCCACCAGAGCTAACCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A3Q8DH98

References