Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2171554..2172208 Replicon chromosome
Accession NZ_CP026216
Organism Citrobacter sp. CFNIH10

Toxin (Protein)


Gene name cptA Uniprot ID A0A3Q8D714
Locus tag C2U53_RS13990 Protein ID WP_044254016.1
Coordinates 2171801..2172208 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0F6TWP9
Locus tag C2U53_RS13985 Protein ID WP_042322123.1
Coordinates 2171554..2171820 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2U53_RS13960 2166769..2168202 - 1434 WP_044264420.1 6-phospho-beta-glucosidase BglA -
C2U53_RS13965 2168322..2169050 - 729 WP_104446027.1 MurR/RpiR family transcriptional regulator -
C2U53_RS13970 2169103..2169414 + 312 WP_042999362.1 N(4)-acetylcytidine aminohydrolase -
C2U53_RS13975 2169577..2170236 + 660 WP_042999363.1 hemolysin III family protein -
C2U53_RS13980 2170317..2171297 - 981 WP_042999364.1 tRNA-modifying protein YgfZ -
C2U53_RS13985 2171554..2171820 + 267 WP_042322123.1 FAD assembly factor SdhE Antitoxin
C2U53_RS13990 2171801..2172208 + 408 WP_044254016.1 protein YgfX Toxin
C2U53_RS13995 2172309..2172830 - 522 WP_042999366.1 flavodoxin FldB -
C2U53_RS14000 2172931..2173827 + 897 WP_042999367.1 site-specific tyrosine recombinase XerD -
C2U53_RS14005 2173851..2174564 + 714 WP_042999368.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
C2U53_RS14010 2174570..2176303 + 1734 WP_104446028.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15863.86 Da        Isoelectric Point: 11.6030

>T93698 WP_044254016.1 NZ_CP026216:2171801-2172208 [Citrobacter sp. CFNIH10]
VVLWQSDLRVSWRAQWLSLLLHGLVAAAILLMPWPLSYTPLWLILLSLVVFDCVRSQRRINARQGEVKLLMDGRLRWQGQ
DWLIVSAPWMIKTGMMLRLRSETGKRQHLWLAADSMDKAEWRDLRRLMMQPSTQG

Download         Length: 408 bp

>T93698 NZ_CP026216:2171801-2172208 [Citrobacter sp. CFNIH10]
GTGGTCCTGTGGCAATCTGATCTCCGCGTCTCATGGCGCGCACAGTGGCTATCACTCCTTCTGCATGGGCTGGTGGCCGC
GGCGATTCTATTAATGCCATGGCCGCTGAGCTACACGCCGCTGTGGTTGATACTGCTTTCGCTGGTGGTATTTGACTGTG
TCCGCAGCCAGCGGCGAATTAACGCCCGTCAGGGAGAGGTCAAACTTCTGATGGATGGACGACTCCGCTGGCAGGGGCAG
GACTGGCTTATCGTCAGTGCACCGTGGATGATCAAAACCGGCATGATGCTGCGCTTGCGCTCAGAAACCGGTAAACGCCA
GCATTTGTGGCTCGCGGCTGACAGTATGGATAAGGCGGAATGGCGAGATTTACGCCGCCTGATGATGCAACCGTCGACGC
AAGGGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10544.06 Da        Isoelectric Point: 5.1496

>AT93698 WP_042322123.1 NZ_CP026216:2171554-2171820 [Citrobacter sp. CFNIH10]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RDRGPVAI

Download         Length: 267 bp

>AT93698 NZ_CP026216:2171554-2171820 [Citrobacter sp. CFNIH10]
ATGGATATTAACAATAAAGCACGTATTCACTGGGCATGCCGACGCGGTATGCGTGAACTCGATATTTCCATCATGCCGTT
TTTCGAACATGAATACGACACGTTGAGTGATGATGAAAAACGTATTTTTATCCGCCTGCTGGAGTGTGATGACCCGGATT
TATTCAACTGGTTGATGAATCACGGTAAACCGGCAGATGCTGAACTGGAGCAGATGGTACGACTCATCCAGACACGGAAT
CGGGATCGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Q8D714

Antitoxin

Source ID Structure
AlphaFold DB A0A0F6TWP9

References