Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2005646..2006172 Replicon chromosome
Accession NZ_CP026216
Organism Citrobacter sp. CFNIH10

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag C2U53_RS13135 Protein ID WP_000323025.1
Coordinates 2005885..2006172 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag C2U53_RS13130 Protein ID WP_000534858.1
Coordinates 2005646..2005885 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2U53_RS13110 2001705..2003045 + 1341 WP_000589001.1 ISNCY family transposase -
C2U53_RS13115 2003688..2004260 + 573 WP_001515348.1 cytochrome b/b6 domain-containing protein -
C2U53_RS13120 2004460..2005383 + 924 WP_000167917.1 cation diffusion facilitator family transporter -
C2U53_RS13130 2005646..2005885 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
C2U53_RS13135 2005885..2006172 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
C2U53_RS13140 2006234..2007334 + 1101 WP_042999247.1 NapC/NirT family cytochrome c -
C2U53_RS13145 2007362..2009809 + 2448 WP_046401402.1 molybdopterin guanine dinucleotide-containing S/N-oxide reductase -
C2U53_RS13150 2009905..2010909 - 1005 WP_042999248.1 ornithine carbamoyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2000084..2001616 1532


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T93696 WP_000323025.1 NZ_CP026216:2005885-2006172 [Citrobacter sp. CFNIH10]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T93696 NZ_CP026216:2005885-2006172 [Citrobacter sp. CFNIH10]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT93696 WP_000534858.1 NZ_CP026216:2005646-2005885 [Citrobacter sp. CFNIH10]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT93696 NZ_CP026216:2005646-2005885 [Citrobacter sp. CFNIH10]
ATGGGTAGCATTAACCTACGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGACTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References