Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 1494313..1494938 Replicon chromosome
Accession NZ_CP026216
Organism Citrobacter sp. CFNIH10

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag C2U53_RS10635 Protein ID WP_104445884.1
Coordinates 1494552..1494938 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag C2U53_RS10630 Protein ID WP_162178932.1
Coordinates 1494313..1494552 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2U53_RS10605 1490277..1490876 + 600 WP_044265152.1 glucose-1-phosphatase -
C2U53_RS10610 1490870..1491742 + 873 WP_044257165.1 virulence factor BrkB family protein -
C2U53_RS10615 1491739..1492176 + 438 WP_044265155.1 D-tyrosyl-tRNA(Tyr) deacylase -
C2U53_RS10620 1492221..1493162 + 942 WP_042998862.1 fatty acid biosynthesis protein FabY -
C2U53_RS10625 1493177..1494103 - 927 WP_104445883.1 alpha/beta hydrolase -
C2U53_RS10630 1494313..1494552 + 240 WP_162178932.1 ribbon-helix-helix domain-containing protein Antitoxin
C2U53_RS10635 1494552..1494938 + 387 WP_104445884.1 type II toxin-antitoxin system VapC family toxin Toxin
C2U53_RS10640 1494969..1495898 - 930 WP_042998866.1 formate dehydrogenase accessory protein FdhE -
C2U53_RS10645 1496043..1496729 - 687 WP_044257174.1 response regulator transcription factor -
C2U53_RS10650 1496734..1498230 - 1497 WP_044257176.1 HAMP domain-containing histidine kinase -
C2U53_RS10655 1498248..1499585 - 1338 WP_086512772.1 VWA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-46)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14385.60 Da        Isoelectric Point: 8.4615

>T93694 WP_104445884.1 NZ_CP026216:1494552-1494938 [Citrobacter sp. CFNIH10]
MQKGPVLFDTNILIDLFSGHQEAQQVLEAYPPQNAISLVTWMEVMVGAKKYHQEYRTRVALSAFNIIGVSQEIAERSVNL
RQEYGMKLPDAIILATAQIHRFALVTRNTRDFAGIPGVITPYQLQAGR

Download         Length: 387 bp

>T93694 NZ_CP026216:1494552-1494938 [Citrobacter sp. CFNIH10]
ATGCAAAAGGGTCCCGTGCTGTTCGATACCAATATCCTGATTGATTTATTCAGCGGGCACCAGGAAGCACAGCAAGTACT
GGAAGCGTATCCGCCGCAGAATGCCATCAGCCTGGTTACCTGGATGGAAGTCATGGTGGGGGCAAAAAAATACCATCAGG
AATATCGTACACGTGTGGCGTTGAGTGCGTTCAACATCATCGGCGTTTCACAGGAAATTGCTGAGCGAAGCGTGAATCTC
AGGCAGGAATATGGGATGAAACTTCCGGACGCGATTATTCTGGCTACCGCGCAGATTCATCGGTTTGCGCTTGTGACGCG
CAACACCAGAGATTTCGCGGGGATACCTGGCGTCATTACGCCTTATCAGTTGCAAGCCGGACGATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9222.37 Da        Isoelectric Point: 4.2075

>AT93694 WP_162178932.1 NZ_CP026216:1494313-1494552 [Citrobacter sp. CFNIH10]
MAGMDMGRILLDLSDEVIKRLDDLKQQRNLPRAELLREAVEQYLERQGQAETTISNALGLWQGCEEDGVEYQRTLREEW

Download         Length: 240 bp

>AT93694 NZ_CP026216:1494313-1494552 [Citrobacter sp. CFNIH10]
ATGGCTGGAATGGACATGGGCAGAATATTACTCGACTTATCCGATGAGGTGATCAAGCGCCTTGACGATCTCAAGCAGCA
GCGGAATCTGCCGCGTGCGGAGTTGTTGCGCGAAGCGGTTGAACAGTACCTTGAAAGGCAGGGACAGGCTGAAACCACGA
TTTCCAATGCGCTGGGGCTCTGGCAGGGCTGTGAGGAAGACGGCGTTGAGTATCAGAGGACGCTACGCGAGGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References