93692

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yafW-ykfI/CbtA-CbeA
Location 81849..82528 Replicon chromosome
Accession NZ_CP026216
Organism Citrobacter sp. CFNIH10

Toxin (Protein)


Gene name ykfI Uniprot ID A0A1B7JLK7
Locus tag C2U53_RS03700 Protein ID WP_003031349.1
Coordinates 82187..82528 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yafW Uniprot ID A0A1B7JLJ2
Locus tag C2U53_RS03695 Protein ID WP_003031347.1
Coordinates 81849..82166 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2U53_RS03675 77942..79939 - 1998 WP_016245729.1 choline BCCT transporter BetT -
C2U53_RS29835 80443..80634 + 192 Protein_78 DUF905 family protein -
C2U53_RS03680 80648..81109 + 462 WP_104445641.1 antirestriction protein -
C2U53_RS03685 81125..81601 + 477 WP_003031345.1 RadC family protein -
C2U53_RS03690 81610..81831 + 222 WP_003031346.1 DUF987 domain-containing protein -
C2U53_RS03695 81849..82166 + 318 WP_003031347.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
C2U53_RS03700 82187..82528 + 342 WP_003031349.1 type IV toxin-antitoxin system toxin YkfI Toxin
C2U53_RS03710 83108..84361 - 1254 WP_042997816.1 glutamate-5-semialdehyde dehydrogenase -
C2U53_RS03715 84373..85476 - 1104 WP_042997817.1 glutamate 5-kinase -
C2U53_RS03720 85764..86816 + 1053 WP_042997818.1 phosphoporin PhoE -
C2U53_RS03725 86896..87297 - 402 WP_042997819.1 sigma factor-binding protein Crl -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12921.01 Da        Isoelectric Point: 9.6543

>T93692 WP_003031349.1 NZ_CP026216:82187-82528 [Citrobacter sp. CFNIH10]
MKTLPATTQRAVKPCLSPVAVWQMLLTRLLEQHYGLTINDTPFCNEAVIKEHIDAGITLADAVNFLVEKYELVRIDRKGF
SWQEQSPYLRAVDILRARQATGLLRQSRNNVVR

Download         Length: 342 bp

>T93692 NZ_CP026216:82187-82528 [Citrobacter sp. CFNIH10]
ATGAAAACTTTACCTGCAACAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATAGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGTAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 12094.74 Da        Isoelectric Point: 7.0370

>AT93692 WP_003031347.1 NZ_CP026216:81849-82166 [Citrobacter sp. CFNIH10]
MSKITWGLQRDITPRLGARLVQEGNRLHYLADRASMTGKFSDIEYRKLDETFPHFIRQMESMLTTGELSTHHAHCVTLYH
NDLTCEADTLGSCGYVYIAIYPTQR

Download         Length: 318 bp

>AT93692 NZ_CP026216:81849-82166 [Citrobacter sp. CFNIH10]
ATGAGCAAAATCACATGGGGTCTGCAGCGTGATATCACGCCACGTCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATGACCGGCAAGTTCAGTGACATCGAATACCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCGCCAGATGGAATCGATGCTGACCACTGGTGAACTCAGCACCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B7JLK7

Antitoxin

Source ID Structure
AlphaFold DB A0A1B7JLJ2

References