Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4410629..4411471 Replicon chromosome
Accession NZ_CP026178
Organism Klebsiella pneumoniae strain KPNIH49

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag C2U49_RS22615 Protein ID WP_040246536.1
Coordinates 4411094..4411471 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag C2U49_RS22610 Protein ID WP_077256055.1
Coordinates 4410629..4411042 (+) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2U49_RS22560 4405764..4406729 + 966 WP_040246521.1 hypothetical protein -
C2U49_RS22565 4406903..4407514 + 612 Protein_4287 IS256 family transposase -
C2U49_RS22575 4407843..4408154 + 312 Protein_4288 hypothetical protein -
C2U49_RS22580 4408205..4408675 + 471 WP_040246523.1 hypothetical protein -
C2U49_RS22585 4408749..4408970 + 222 WP_040246525.1 hypothetical protein -
C2U49_RS22590 4409026..4409217 + 192 WP_100097506.1 DUF905 family protein -
C2U49_RS22595 4409457..4409927 + 471 WP_040246527.1 antirestriction protein -
C2U49_RS22600 4409939..4410418 + 480 WP_040246529.1 DNA repair protein RadC -
C2U49_RS22605 4410439..4410660 + 222 WP_040246532.1 DUF987 domain-containing protein -
C2U49_RS22610 4410629..4411042 + 414 WP_077256055.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
C2U49_RS22615 4411094..4411471 + 378 WP_040246536.1 TA system toxin CbtA family protein Toxin
C2U49_RS22620 4411468..4411959 + 492 WP_040246538.1 hypothetical protein -
C2U49_RS22625 4411989..4412174 + 186 WP_040246540.1 DUF957 domain-containing protein -
C2U49_RS22630 4412256..4413101 + 846 WP_040246542.1 DUF4942 domain-containing protein -
C2U49_RS22635 4413245..4414042 + 798 WP_040246544.1 helix-turn-helix transcriptional regulator -
C2U49_RS22640 4414358..4415469 + 1112 WP_103215769.1 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4385644..4426211 40567
- flank IS/Tn - - 4406903..4407622 719


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(33-132)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14021.73 Da        Isoelectric Point: 5.5540

>T93668 WP_040246536.1 NZ_CP026178:4411094-4411471 [Klebsiella pneumoniae]
MQTQPLSSTQEASPRPSQVDIWQQLLSHLLDRHYGLTLNDTPFGHDGVIQEHIDAGISLCDAVNVIVEKYDLVRTDRPGF
SAETQSPLISSIDILRARKATGLMTRNDYRTVTDITTGKYREVQP

Download         Length: 378 bp

>T93668 NZ_CP026178:4411094-4411471 [Klebsiella pneumoniae]
ATGCAAACCCAACCGCTATCCTCCACGCAGGAGGCTTCGCCACGCCCGTCACAGGTGGATATCTGGCAGCAGCTTCTGAG
TCACCTGCTGGATCGTCACTACGGTCTGACGCTTAACGACACGCCATTTGGTCACGATGGCGTGATTCAGGAGCATATCG
ACGCGGGTATCTCACTGTGCGATGCCGTGAATGTTATCGTGGAAAAGTACGATCTGGTGCGCACCGATCGTCCCGGTTTC
AGCGCAGAAACACAGTCGCCGCTTATCAGCAGTATCGATATTCTCCGCGCCCGCAAAGCCACCGGGCTGATGACCCGCAA
CGACTACAGAACGGTGACCGACATCACCACCGGTAAATACCGTGAGGTGCAGCCATGA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 14964.07 Da        Isoelectric Point: 6.8319

>AT93668 WP_077256055.1 NZ_CP026178:4410629-4411042 [Klebsiella pneumoniae]
MSSCAVSRSINVNLRKAKLSNEIPAVNHDIAEPWWGLKPTVTPCFGARLVQEGNQVHYLADRASITGQFSEADLRHLDQA
FPVLLKQLELMLVSGELNPHHQHGVTLYAKGLTCEADSLGSHGYIYIAIYPTPAATA

Download         Length: 414 bp

>AT93668 NZ_CP026178:4410629-4411042 [Klebsiella pneumoniae]
ATGTCGTCCTGCGCAGTGTCACGCTCAATTAACGTTAATTTAAGGAAAGCTAAATTGTCGAATGAAATACCGGCAGTAAA
CCACGATATCGCTGAACCCTGGTGGGGCCTTAAGCCCACCGTCACACCGTGCTTTGGCGCACGACTGGTGCAGGAGGGCA
ACCAGGTGCACTATCTCGCCGACCGCGCCAGCATCACCGGTCAGTTCAGCGAGGCGGATTTACGCCATCTTGACCAGGCC
TTTCCGGTACTACTCAAACAGCTGGAATTGATGCTGGTTTCCGGTGAACTCAATCCTCACCATCAACACGGCGTTACGCT
CTACGCAAAAGGGTTGACCTGCGAAGCCGATTCACTCGGCTCGCATGGCTACATTTATATTGCGATTTATCCAACGCCTG
CAGCAACCGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References