Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2918214..2918730 Replicon chromosome
Accession NZ_CP026177
Organism Klebsiella pneumoniae strain KPNIH50

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag C2U50_RS18985 Protein ID WP_004178374.1
Coordinates 2918446..2918730 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag C2U50_RS18980 Protein ID WP_002886901.1
Coordinates 2918214..2918456 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2U50_RS18965 2914242..2914982 + 741 WP_002886899.1 KDGP aldolase family protein -
C2U50_RS18970 2915049..2916203 + 1155 WP_023159544.1 lactonase family protein -
C2U50_RS18975 2916226..2918136 + 1911 WP_040236557.1 BglG family transcription antiterminator -
C2U50_RS18980 2918214..2918456 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
C2U50_RS18985 2918446..2918730 + 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C2U50_RS18990 2918734..2919198 - 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
C2U50_RS18995 2919506..2921644 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
C2U50_RS19000 2922001..2922744 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
C2U50_RS33370 2922747..2922920 - 174 WP_002886906.1 hypothetical protein -
C2U50_RS19005 2923005..2923313 + 309 WP_002886907.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T93642 WP_004178374.1 NZ_CP026177:2918446-2918730 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T93642 NZ_CP026177:2918446-2918730 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT93642 WP_002886901.1 NZ_CP026177:2918214-2918456 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT93642 NZ_CP026177:2918214-2918456 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References