Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1505897..1506554 Replicon chromosome
Accession NZ_CP026177
Organism Klebsiella pneumoniae strain KPNIH50

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag C2U50_RS11745 Protein ID WP_002916310.1
Coordinates 1505897..1506307 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag C2U50_RS11750 Protein ID WP_002916312.1
Coordinates 1506288..1506554 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2U50_RS11725 1501897..1503630 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
C2U50_RS11730 1503636..1504349 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
C2U50_RS11735 1504372..1505268 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
C2U50_RS11740 1505369..1505890 + 522 WP_002916308.1 flavodoxin FldB -
C2U50_RS11745 1505897..1506307 - 411 WP_002916310.1 protein YgfX Toxin
C2U50_RS11750 1506288..1506554 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
C2U50_RS11755 1506800..1507783 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
C2U50_RS11760 1507934..1508593 - 660 WP_002916317.1 hemolysin III family protein -
C2U50_RS11765 1508757..1509068 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
C2U50_RS11770 1509118..1509846 + 729 WP_023313614.1 MurR/RpiR family transcriptional regulator -
C2U50_RS11775 1509965..1511398 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T93637 WP_002916310.1 NZ_CP026177:c1506307-1505897 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T93637 NZ_CP026177:c1506307-1505897 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT93637 WP_002916312.1 NZ_CP026177:c1506554-1506288 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT93637 NZ_CP026177:c1506554-1506288 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References