Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 47839..48365 Replicon plasmid pKPC-0cc9
Accession NZ_CP026175
Organism Klebsiella pneumoniae strain KPNIH50

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag C2U50_RS02780 Protein ID WP_000323025.1
Coordinates 48078..48365 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID J5W3H0
Locus tag C2U50_RS02775 Protein ID WP_004196370.1
Coordinates 47839..48078 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2U50_RS02745 43176..43368 - 193 Protein_46 MFS transporter -
C2U50_RS02750 43398..44375 + 978 WP_004196334.1 chromate resistance protein -
C2U50_RS02755 44332..45708 + 1377 Protein_48 chromate efflux transporter -
C2U50_RS02760 45739..46428 - 690 WP_004196322.1 hypothetical protein -
C2U50_RS02765 46442..47179 - 738 WP_008460272.1 HupE/UreJ family protein -
C2U50_RS02770 47223..47588 - 366 WP_009651956.1 hypothetical protein -
C2U50_RS02775 47839..48078 + 240 WP_004196370.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
C2U50_RS02780 48078..48365 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
C2U50_RS02785 48416..49450 - 1035 Protein_54 IS481 family transposase -
C2U50_RS02790 49522..49680 + 159 WP_014343509.1 type I toxin-antitoxin system Hok family toxin -
C2U50_RS02795 50378..50650 + 273 WP_032425552.1 hypothetical protein -
C2U50_RS02800 50647..50997 + 351 WP_032425551.1 hypothetical protein -
C2U50_RS02805 51012..51329 + 318 WP_015065519.1 hypothetical protein -
C2U50_RS02815 52170..52526 + 357 WP_019706019.1 hypothetical protein -
C2U50_RS02820 52587..52799 + 213 WP_019706020.1 hypothetical protein -
C2U50_RS02825 52810..53034 + 225 WP_014343499.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaKPC-2 - 1..172259 172259


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T93631 WP_000323025.1 NZ_CP026175:48078-48365 [Klebsiella pneumoniae]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T93631 NZ_CP026175:48078-48365 [Klebsiella pneumoniae]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9018.43 Da        Isoelectric Point: 4.3894

>AT93631 WP_004196370.1 NZ_CP026175:47839-48078 [Klebsiella pneumoniae]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLCNPKPVRVTLDEL

Download         Length: 240 bp

>AT93631 NZ_CP026175:47839-48078 [Klebsiella pneumoniae]
ATGGGTAGCATTAACCTACGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGACTTTGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4QRH4

References