Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3883516..3884135 Replicon chromosome
Accession NZ_CP026164
Organism Klebsiella pneumoniae strain F81

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag C2M15_RS19245 Protein ID WP_002892050.1
Coordinates 3883917..3884135 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag C2M15_RS19240 Protein ID WP_002892066.1
Coordinates 3883516..3883890 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2M15_RS19230 3878668..3879861 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
C2M15_RS19235 3879884..3883030 + 3147 WP_004147373.1 multidrug efflux RND transporter permease subunit -
C2M15_RS19240 3883516..3883890 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
C2M15_RS19245 3883917..3884135 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
C2M15_RS19250 3884294..3884860 + 567 WP_002892030.1 maltose O-acetyltransferase -
C2M15_RS28105 3884832..3884972 - 141 WP_004147370.1 hypothetical protein -
C2M15_RS19255 3884993..3885463 + 471 WP_002892026.1 YlaC family protein -
C2M15_RS19260 3885438..3886889 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
C2M15_RS19265 3886990..3887688 + 699 WP_040220001.1 GNAT family N-acetyltransferase -
C2M15_RS19270 3887685..3887825 - 141 WP_040219999.1 type B 50S ribosomal protein L36 -
C2M15_RS19275 3887825..3888088 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T93620 WP_002892050.1 NZ_CP026164:3883917-3884135 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T93620 NZ_CP026164:3883917-3884135 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT93620 WP_002892066.1 NZ_CP026164:3883516-3883890 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT93620 NZ_CP026164:3883516-3883890 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References