Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4790777..4791293 Replicon chromosome
Accession NZ_CP026162
Organism Klebsiella pneumoniae strain F13

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag C2M13_RS23770 Protein ID WP_002886902.1
Coordinates 4790777..4791061 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag C2M13_RS23775 Protein ID WP_002886901.1
Coordinates 4791051..4791293 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2M13_RS23745 4786172..4786480 - 309 WP_004178377.1 PTS sugar transporter subunit IIB -
C2M13_RS28290 4786565..4786738 + 174 WP_002886906.1 hypothetical protein -
C2M13_RS23750 4786741..4787484 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
C2M13_RS23760 4787841..4789979 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
C2M13_RS23765 4790309..4790773 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
C2M13_RS23770 4790777..4791061 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C2M13_RS23775 4791051..4791293 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
C2M13_RS23780 4791371..4793281 - 1911 WP_009486549.1 BglG family transcription antiterminator -
C2M13_RS23785 4793304..4794458 - 1155 WP_002886900.1 lactonase family protein -
C2M13_RS23790 4794525..4795265 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T93602 WP_002886902.1 NZ_CP026162:c4791061-4790777 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T93602 NZ_CP026162:c4791061-4790777 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT93602 WP_002886901.1 NZ_CP026162:c4791293-4791051 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT93602 NZ_CP026162:c4791293-4791051 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References