Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 53306..53949 Replicon plasmid pF93-1_1
Accession NZ_CP026161
Organism Klebsiella pneumoniae strain F93-1

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag C2M21_RS26260 Protein ID WP_023345587.1
Coordinates 53533..53949 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag C2M21_RS26255 Protein ID WP_023345588.1
Coordinates 53306..53536 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2M21_RS26230 49398..49826 - 429 WP_023345594.1 nuclear transport factor 2 family protein -
C2M21_RS26235 49939..50784 - 846 WP_023345593.1 SDR family oxidoreductase -
C2M21_RS26240 50887..51282 + 396 WP_023345592.1 helix-turn-helix transcriptional regulator -
C2M21_RS26245 51394..51978 + 585 WP_023345591.1 TetR/AcrR family transcriptional regulator -
C2M21_RS26250 52046..52888 + 843 WP_064081525.1 nitroreductase family protein -
C2M21_RS26255 53306..53536 + 231 WP_023345588.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
C2M21_RS26260 53533..53949 + 417 WP_023345587.1 type II toxin-antitoxin system VapC family toxin Toxin
C2M21_RS26265 54041..55444 - 1404 WP_129059596.1 glycoside hydrolase family 1 protein -
C2M21_RS26270 55454..57328 - 1875 WP_064081469.1 beta-glucoside-specific PTS transporter subunit IIABC -
C2M21_RS26275 57718..58353 - 636 WP_064081470.1 DUF1349 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - ybtS / ybtX / ybtQ / ybtP / ybtA / irp2 / irp1 / ybtU / ybtT / ybtE / fyuA 1..165465 165465


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-48)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15082.55 Da        Isoelectric Point: 7.8644

>T93588 WP_023345587.1 NZ_CP026161:53533-53949 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFERVPGLMLEDWVN

Download         Length: 417 bp

>T93588 NZ_CP026161:53533-53949 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTACGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGATGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGCGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCGGCCGGCGCCGTCCTGGTGACGAACAATGTGCGGGAGTTTGAGCGGGTGCCGGGCCTGATGCTGG
AAGACTGGGTGAATTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8677.73 Da        Isoelectric Point: 4.4563

>AT93588 WP_023345588.1 NZ_CP026161:53306-53536 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFAP

Download         Length: 231 bp

>AT93588 NZ_CP026161:53306-53536 [Klebsiella pneumoniae]
ATGAGAACCGTATCTATTTTTAAAAACGGCAACAACCGCGCCATCCGCCTGCCCCGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTCGAGATCGTCCGGGAAGGGGATAGCATCATCCTGCGTCCCGTCCGGCCGACATGGGGCTCGTTCGCGCAACTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGCGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References