Detailed information of TA system TA093583

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4644847..4645363
• Replicon: chromosome
• Accession: NZ_CP026160
• Organism: Klebsiella pneumoniae strain F93-1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: C2M21_RS23120
• Protein ID: WP_117043694.1
• Coordinates: 4644847..4645131 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: R4Y888
• Locus tag: C2M21_RS23125
• Protein ID: WP_002886901.1
• Coordinates: 4645121..4645363 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C2M21_RS23100	4640242..4640550	-	309	WP_004894688.1	PTS sugar transporter subunit IIB	-
C2M21_RS27650	4640635..4640808	+	174	WP_002886906.1	hypothetical protein	-
C2M21_RS23105	4640811..4641554	+	744	WP_002886905.1	MurR/RpiR family transcriptional regulator	-
C2M21_RS23110	4641911..4644049	+	2139	WP_103215710.1	anaerobic ribonucleoside-triphosphate reductase	-
C2M21_RS23115	4644379..4644843	+	465	WP_048968808.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
C2M21_RS23120	4644847..4645131	-	285	WP_117043694.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
C2M21_RS23125	4645121..4645363	-	243	WP_002886901.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
C2M21_RS23130	4645441..4647351	-	1911	WP_032412857.1	BglG family transcription antiterminator	-
C2M21_RS23135	4647374..4648528	-	1155	WP_004178372.1	lactonase family protein	-
C2M21_RS23140	4648595..4649335	-	741	WP_004186692.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11116.01 Da
• Isoelectric Point: 10.4962

>T93583 WP_117043694.1 NZ_CP026160:c4645131-4644847 [Klebsiella pneumoniae]
MTYELAFDPRAWREWQKPGETVKKQFKNKLQQIMQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T93583 NZ_CP026160:c4645131-4644847 [Klebsiella pneumoniae]
ATGACCTATGAACTGGCGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTATGCAGAATCTGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9045.55 Da
• Isoelectric Point: 6.3340

>AT93583 WP_002886901.1 NZ_CP026160:c4645363-4645121 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT93583 NZ_CP026160:c4645363-4645121 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GLP0