Detailed information of TA system TA093564

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): ypjF-yeeU/CbtA-CbeA
• Location: 4637868..4638589
• Replicon: chromosome
• Accession: NZ_CP026159
• Organism: Klebsiella pneumoniae strain F89-1

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: C2M18_RS23165
• Protein ID: WP_087835501.1
• Coordinates: 4637868..4638185 (-)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: C2M18_RS23170
• Protein ID: WP_117031222.1
• Coordinates: 4638224..4638589 (-)
• Length: 122 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C2M18_RS23135	4633141..4633620	+	480	WP_002887049.1	type VI secretion system tube protein Hcp	-
C2M18_RS23140	4633812..4634135	-	324	Protein_4438	hypothetical protein	-
C2M18_RS23145	4634154..4635265	-	1112	Protein_4439	IS3 family transposase	-
C2M18_RS23160	4636062..4637564	-	1503	WP_087835499.1	RNA-dependent DNA polymerase	-
C2M18_RS23165	4637868..4638185	-	318	WP_087835501.1	TA system toxin CbtA family protein	Toxin
C2M18_RS23170	4638224..4638589	-	366	WP_117031222.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
C2M18_RS23175	4638615..4638836	-	222	WP_087835505.1	DUF987 family protein	-
C2M18_RS23180	4638833..4639375	-	543	WP_087835507.1	DNA repair protein RadC	-
C2M18_RS23185	4639388..4639831	-	444	WP_087835508.1	antirestriction protein	-
C2M18_RS23190	4639862..4640683	-	822	WP_087835510.1	DUF945 domain-containing protein	-
C2M18_RS23195	4640782..4641012	-	231	WP_087835512.1	DUF905 domain-containing protein	-
C2M18_RS23200	4641084..4641533	-	450	WP_014226752.1	hypothetical protein	-
C2M18_RS23205	4641530..4641982	-	453	WP_087835514.1	hypothetical protein	-
C2M18_RS23210	4642019..4642588	-	570	WP_032950001.1	hypothetical protein	-
C2M18_RS23215	4642588..4643292	-	705	WP_087835516.1	WYL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4632791..4663085	30294

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-103)

Antitoxin

• Antitoxin CbeA (17-117)

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12152.96 Da
• Isoelectric Point: 6.2150

>T93564 WP_087835501.1 NZ_CP026159:c4638185-4637868 [Klebsiella pneumoniae]
MQILSSQPTQAAQPCLSPVEIWQRLLTHLLLKHYGLALNDTPFSNETVIQEHIDAGITMANAMNFLVEKYELVRIDRREF
DWQEKSPYLQAVDILRARQATGMRQ

Nucleotide

• Length: 318 bp

>T93564 NZ_CP026159:c4638185-4637868 [Klebsiella pneumoniae]
ATGCAAATCTTATCATCACAACCGACACAGGCGGCTCAGCCCTGTCTTTCGCCCGTCGAAATCTGGCAACGGCTGCTGAC
TCATCTGTTGTTGAAGCACTATGGTCTGGCGCTGAATGACACACCATTCAGTAATGAAACCGTTATTCAGGAGCACATTG
ATGCCGGTATCACTATGGCTAACGCTATGAATTTTCTGGTAGAAAAATATGAGTTGGTTCGTATTGACCGCAGGGAATTC
GACTGGCAAGAAAAGTCCCCATACCTGCAGGCTGTCGATATTCTGCGGGCGCGACAGGCTACAGGTATGCGGCAATGA

Antitoxin

Protein

• Length: 122 a.a.
• Molecular weight: 13423.95 Da
• Isoelectric Point: 4.7864

>AT93564 WP_117031222.1 NZ_CP026159:c4638589-4638224 [Klebsiella pneumoniae]
MNNHSESGTKPENPACQQWGLQSTITPCFGARLVQEGNRLHFLADRAGFNGAFSDDDALHLEQTFPLILKQLEMMLTSGE
LSPRHQHSVTLYHNGLSCEADTLGSCGYIYIAIYPDQTEPQ

Nucleotide

• Length: 366 bp

>AT93564 NZ_CP026159:c4638589-4638224 [Klebsiella pneumoniae]
ATGAACAATCACTCAGAATCCGGTACAAAGCCGGAGAATCCCGCCTGCCAGCAGTGGGGGCTACAGAGTACGATCACACC
CTGTTTTGGAGCTCGTCTGGTGCAGGAAGGCAACCGCCTGCATTTTCTCGCTGACCGGGCCGGATTCAACGGTGCTTTCA
GTGACGATGACGCGCTACACCTAGAGCAGACCTTTCCGTTGATACTTAAGCAACTGGAGATGATGCTCACCAGCGGAGAG
CTTTCTCCCCGACATCAGCACTCCGTCACGCTGTATCACAATGGACTATCTTGCGAAGCCGATACACTCGGCTCCTGTGG
TTATATCTACATCGCTATTTATCCCGACCAGACTGAGCCGCAGTAA