Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4551110..4551626 Replicon chromosome
Accession NZ_CP026157
Organism Klebsiella pneumoniae strain F93-2

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag C2M12_RS22530 Protein ID WP_002886902.1
Coordinates 4551110..4551394 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag C2M12_RS22535 Protein ID WP_002886901.1
Coordinates 4551384..4551626 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2M12_RS22505 4546526..4546834 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
C2M12_RS26800 4546919..4547092 + 174 WP_032410138.1 hypothetical protein -
C2M12_RS22510 4547095..4547838 + 744 WP_021441079.1 MurR/RpiR family transcriptional regulator -
C2M12_RS22520 4548195..4550333 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
C2M12_RS22525 4550642..4551106 + 465 WP_023302390.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
C2M12_RS22530 4551110..4551394 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C2M12_RS22535 4551384..4551626 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
C2M12_RS22540 4551704..4553614 - 1911 WP_009486549.1 BglG family transcription antiterminator -
C2M12_RS22545 4553637..4554791 - 1155 WP_023302389.1 lactonase family protein -
C2M12_RS22550 4554858..4555598 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T93543 WP_002886902.1 NZ_CP026157:c4551394-4551110 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T93543 NZ_CP026157:c4551394-4551110 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT93543 WP_002886901.1 NZ_CP026157:c4551626-4551384 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT93543 NZ_CP026157:c4551626-4551384 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References