Detailed information of TA system TA093512

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 910427..911199
• Replicon: chromosome
• Accession: NZ_CP026155
• Organism: Klebsiella pneumoniae strain B12(AN)

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: A0A443UJW7
• Locus tag: C2M23_RS04675
• Protein ID: WP_065523303.1
• Coordinates: 910810..911199 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: C2M23_RS04670
• Protein ID: WP_170324126.1
• Coordinates: 910427..910753 (+)
• Length: 109 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C2M23_RS04640	906286..907374	+	1089	WP_065523308.1	patatin-like phospholipase family protein	-
C2M23_RS28755	907330..907605	-	276	Protein_895	transposase	-
C2M23_RS04650	908340..909161	+	822	WP_065523307.1	DUF945 domain-containing protein	-
C2M23_RS04655	909194..909643	+	450	WP_065523306.1	antirestriction protein	-
C2M23_RS04660	909655..910134	+	480	WP_065523305.1	DNA repair protein RadC	-
C2M23_RS04665	910148..910369	+	222	WP_004192297.1	DUF987 domain-containing protein	-
C2M23_RS04670	910427..910753	+	327	WP_170324126.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
C2M23_RS04675	910810..911199	+	390	WP_065523303.1	TA system toxin CbtA family protein	Toxin
C2M23_RS04680	911272..912111	+	840	WP_065523302.1	DUF4942 domain-containing protein	-
C2M23_RS04685	912452..913840	-	1389	WP_004151784.1	MFS transporter	-
C2M23_RS04690	913970..914899	+	930	WP_002916293.1	LysR family transcriptional regulator	-
C2M23_RS04695	915263..916066	-	804	WP_002916291.1	carboxymuconolactone decarboxylase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-111)

Antitoxin

• Antitoxin CbeA (4-103)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 14411.53 Da
• Isoelectric Point: 9.8627

>T93512 WP_065523303.1 NZ_CP026155:910810-911199 [Klebsiella pneumoniae]
MQTKSSPLMRAASSRPSPVYIWQTLLTSLLAQHYGLTLSDTPFSDEQVIQQHIDAGISLVDALNFIVEKYELVRTDRPGF
SILTQSPFITPIDILRARKATGLMNRDTYKEVTAITRGQHPQVSAPGKR

Nucleotide

• Length: 390 bp

>T93512 NZ_CP026155:910810-911199 [Klebsiella pneumoniae]
ATGCAAACCAAATCATCCCCCCTCATGCGGGCGGCATCGTCACGTCCGTCTCCCGTGTATATCTGGCAGACCCTGCTGAC
CAGCCTGCTGGCACAACACTATGGACTCACGCTTAGCGATACGCCGTTCAGTGATGAACAGGTCATTCAGCAACATATTG
ATGCCGGTATCTCGCTGGTTGATGCCCTGAATTTTATCGTTGAGAAGTATGAACTGGTCCGCACTGACCGCCCAGGCTTC
AGCATCCTGACGCAGTCTCCGTTTATCACACCCATAGATATCCTCCGGGCCAGGAAAGCAACGGGGCTGATGAACCGTGA
CACGTATAAAGAGGTGACGGCGATTACCAGAGGGCAACATCCGCAGGTCAGCGCTCCAGGCAAGCGATGA

Antitoxin

Protein

• Length: 109 a.a.
• Molecular weight: 12132.81 Da
• Isoelectric Point: 6.6283

>AT93512 WP_170324126.1 NZ_CP026155:910427-910753 [Klebsiella pneumoniae]
ISEPWWGLRRSTSPCFGARLVQEGNRLHYLADRANFDGQFCDADLRHLDQSFPVLMKQLELMLTSGELNPRHQHGIILYA
KGLTCEADTLGSHGYVYIAIYPTPVATA

Nucleotide

• Length: 327 bp

>AT93512 NZ_CP026155:910427-910753 [Klebsiella pneumoniae]
ATCAGCGAACCCTGGTGGGGACTCAGACGCAGTACCTCCCCGTGTTTTGGTGCCCGTCTGGTCCAGGAGGGGAACCGCCT
GCATTACCTGGCTGACCGCGCGAACTTTGATGGTCAGTTCTGTGATGCGGATTTGCGCCATCTTGACCAGTCTTTCCCGG
TATTAATGAAACAGCTGGAGTTAATGCTCACCAGCGGTGAACTGAACCCCCGTCATCAGCATGGCATCATACTGTATGCA
AAAGGTCTGACCTGCGAGGCGGATACGCTCGGTTCGCATGGCTATGTTTATATCGCGATTTATCCCACTCCCGTCGCCAC
GGCATAA

Structures

Toxin

• AlphaFold DB: A0A443UJW7