Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4883604..4884120 Replicon chromosome
Accession NZ_CP026149
Organism Klebsiella pneumoniae strain F138

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag C2M09_RS24640 Protein ID WP_002886902.1
Coordinates 4883604..4883888 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag C2M09_RS24645 Protein ID WP_002886901.1
Coordinates 4883878..4884120 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2M09_RS24620 4879088..4879396 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
C2M09_RS31095 4879481..4879654 + 174 WP_002886906.1 hypothetical protein -
C2M09_RS24625 4879657..4880400 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
C2M09_RS24630 4880757..4882895 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
C2M09_RS24635 4883136..4883600 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
C2M09_RS24640 4883604..4883888 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C2M09_RS24645 4883878..4884120 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
C2M09_RS24650 4884198..4886108 - 1911 WP_004152270.1 BglG family transcription antiterminator -
C2M09_RS24655 4886131..4887285 - 1155 WP_002886900.1 lactonase family protein -
C2M09_RS24660 4887351..4888091 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element sul1 / qacE / aadA2 / cmlA1 / ant(2'')-Ia / aph(3'')-Ib / aph(6)-Id - 4832978..5044720 211742


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T93499 WP_002886902.1 NZ_CP026149:c4883888-4883604 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T93499 NZ_CP026149:c4883888-4883604 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT93499 WP_002886901.1 NZ_CP026149:c4884120-4883878 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT93499 NZ_CP026149:c4884120-4883878 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References