Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4138586..4139205 Replicon chromosome
Accession NZ_CP026145
Organism Klebsiella pneumoniae strain F132

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag C2M08_RS20935 Protein ID WP_002892050.1
Coordinates 4138987..4139205 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag C2M08_RS20930 Protein ID WP_002892066.1
Coordinates 4138586..4138960 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2M08_RS20920 4133738..4134931 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
C2M08_RS20925 4134954..4138100 + 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit -
C2M08_RS20930 4138586..4138960 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
C2M08_RS20935 4138987..4139205 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
C2M08_RS20940 4139364..4139930 + 567 WP_002892030.1 maltose O-acetyltransferase -
C2M08_RS30380 4139902..4140042 - 141 WP_004147370.1 hypothetical protein -
C2M08_RS20945 4140063..4140533 + 471 WP_002892026.1 YlaC family protein -
C2M08_RS20950 4140508..4141959 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
C2M08_RS20955 4142060..4142758 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
C2M08_RS20960 4142755..4142895 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
C2M08_RS20965 4142895..4143158 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T93475 WP_002892050.1 NZ_CP026145:4138987-4139205 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T93475 NZ_CP026145:4138987-4139205 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT93475 WP_002892066.1 NZ_CP026145:4138586-4138960 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT93475 NZ_CP026145:4138586-4138960 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References