Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4880413..4880929 Replicon chromosome
Accession NZ_CP026136
Organism Klebsiella pneumoniae strain F77

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag C2L62_RS24615 Protein ID WP_002886902.1
Coordinates 4880413..4880697 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag C2L62_RS24620 Protein ID WP_002886901.1
Coordinates 4880687..4880929 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2L62_RS24595 4875897..4876205 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
C2L62_RS30900 4876290..4876463 + 174 WP_002886906.1 hypothetical protein -
C2L62_RS24600 4876466..4877209 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
C2L62_RS24605 4877566..4879704 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
C2L62_RS24610 4879945..4880409 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
C2L62_RS24615 4880413..4880697 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C2L62_RS24620 4880687..4880929 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
C2L62_RS24625 4881007..4882917 - 1911 WP_004152270.1 BglG family transcription antiterminator -
C2L62_RS24630 4882940..4884094 - 1155 WP_002886900.1 lactonase family protein -
C2L62_RS24635 4884160..4884900 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element sul1 / qacE / aadA2 / cmlA1 / ant(2'')-Ia / aph(3'')-Ib / aph(6)-Id - 4829787..5041529 211742


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T93426 WP_002886902.1 NZ_CP026136:c4880697-4880413 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T93426 NZ_CP026136:c4880697-4880413 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT93426 WP_002886901.1 NZ_CP026136:c4880929-4880687 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT93426 NZ_CP026136:c4880929-4880687 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References