Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 2421785..2422438 Replicon chromosome
Accession NZ_CP026125
Organism Acinetobacter baumannii strain ABNIH28

Toxin (Protein)


Gene name cptA Uniprot ID A0A2S4T466
Locus tag C2U32_RS11985 Protein ID WP_000607071.1
Coordinates 2421785..2422174 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID N9LG27
Locus tag C2U32_RS11990 Protein ID WP_001288212.1
Coordinates 2422181..2422438 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2U32_RS11960 2418167..2418376 + 210 WP_000745523.1 YheV family putative metal-binding protein -
C2U32_RS11970 2418553..2419098 - 546 Protein_2328 hypothetical protein -
C2U32_RS11975 2419286..2419852 - 567 WP_000651536.1 rhombosortase -
C2U32_RS11980 2419930..2421015 - 1086 WP_000049106.1 hypothetical protein -
C2U32_RS11985 2421785..2422174 - 390 WP_000607071.1 membrane protein Toxin
C2U32_RS11990 2422181..2422438 - 258 WP_001288212.1 succinate dehydrogenase assembly factor 2 Antitoxin
C2U32_RS11995 2422626..2423798 + 1173 WP_103270882.1 acyl-CoA dehydrogenase family protein -
C2U32_RS12000 2423847..2425337 - 1491 WP_000415132.1 NAD(P)/FAD-dependent oxidoreductase -
C2U32_RS12005 2425519..2425896 - 378 WP_001216380.1 50S ribosomal protein L17 -
C2U32_RS12010 2425915..2426922 - 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15649.98 Da        Isoelectric Point: 10.4623

>T93356 WP_000607071.1 NZ_CP026125:c2422174-2421785 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAILFYQLMPLLWWLVVISLLFISFIFFLKRPQLAKIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T93356 NZ_CP026125:c2422174-2421785 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AATTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCAAAAATTGCCTATTTAGATAAAAAACTATGGTCGCTTGCTTATCACTCACAGAACACCATT
TCTCGCGTCAAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGATCTACTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10332.79 Da        Isoelectric Point: 4.6247

>AT93356 WP_001288212.1 NZ_CP026125:c2422438-2422181 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKAEPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT93356 NZ_CP026125:c2422438-2422181 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGAGCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTCGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S4T466

Antitoxin

Source ID Structure
AlphaFold DB N9LG27

References