Detailed information of TA system TA093355

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 1069755..1071391
• Replicon: chromosome
• Accession: NZ_CP026125
• Organism: Acinetobacter baumannii strain ABNIH28

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A2I8CRD3
• Locus tag: C2U32_RS05385
• Protein ID: WP_000737054.1
• Coordinates: 1070060..1071391 (-)
• Length: 444 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: C2U32_RS05380
• Protein ID: WP_001101311.1
• Coordinates: 1069755..1070063 (-)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C2U32_RS05360	1065416..1066180	-	765	WP_000537342.1	hypothetical protein	-
C2U32_RS05365	1066194..1067993	-	1800	WP_000269398.1	KAP family P-loop domain protein	-
C2U32_RS05370	1068483..1069031	-	549	WP_025465053.1	TetR/AcrR family transcriptional regulator	-
C2U32_RS05380	1069755..1070063	-	309	WP_001101311.1	helix-turn-helix domain-containing protein	Antitoxin
C2U32_RS05385	1070060..1071391	-	1332	WP_000737054.1	type II toxin-antitoxin system HipA family toxin	Toxin
C2U32_RS05390	1071687..1072127	+	441	WP_000193124.1	HD domain-containing protein	-
C2U32_RS05395	1072162..1072806	-	645	WP_000817299.1	hypothetical protein	-
C2U32_RS05400	1072818..1073789	-	972	WP_086384441.1	acid phosphatase	-
C2U32_RS05405	1073917..1075080	-	1164	WP_001044497.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (167-359)

Antitoxin

• Cro/C1-type helix-turn-helix domain (29-82)

Sequences

Toxin

Protein

• Length: 444 a.a.
• Molecular weight: 51171.17 Da
• Isoelectric Point: 4.7950

>T93355 WP_000737054.1 NZ_CP026125:c1071391-1070060 [Acinetobacter baumannii]
MKKLTIQALLNKNWIDIAELKLLEPKLGSASASELEYELDYAIQYLDRRDEHACSLSLPVQILIKHESDTWFGFLDDIVP
SGAARRYWVNYLDLQRLTYAEQESILLEKGGMAPVGNLRIKEALPPLNPDSTLHLRYFSKEDVAERNIDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPEQKVWIDTYQEQFDQPDQHYLVKFPRNKRSEIDCDILRAEYYYYQILNELGFNTIETTQM
QLIEGTKYPSLWLPRFDTEWCDQYWHRYGLESVYSVLNKSSGSHLNHFEVIEDLCRLLTSIDSDFDVPQFICEWLQRDLL
NIIFGNSDNHGRNTSFIKKSGKIYLSPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWAQITQKLAPWCDPDLSLATLR
TLANNLLGLKQRLVDKGVPKQIIEIPALSFDYIEAKLKRWELL

Nucleotide

• Length: 1332 bp

>T93355 NZ_CP026125:c1071391-1070060 [Acinetobacter baumannii]
ATGAAAAAATTAACGATACAGGCTTTACTAAATAAAAACTGGATAGATATAGCAGAACTAAAACTGCTGGAACCTAAGTT
GGGTTCGGCTAGCGCCAGTGAACTAGAATATGAATTGGATTATGCAATTCAATATTTAGACAGACGAGATGAGCACGCCT
GTAGTTTATCACTTCCTGTACAAATTCTTATCAAACACGAATCGGACACATGGTTTGGCTTTTTAGATGATATTGTTCCA
TCTGGCGCTGCACGCCGTTATTGGGTGAATTATCTAGATTTACAACGCTTAACCTATGCGGAACAAGAAAGTATTCTATT
AGAAAAAGGTGGGATGGCACCTGTTGGTAATTTACGAATTAAAGAAGCATTACCTCCACTAAACCCAGATTCAACCTTGC
ACTTACGTTATTTTTCTAAGGAAGATGTGGCTGAGCGTAATATTGATTTTCTGGAATATGCTCAACAAATGGGAGCTATT
AGTGGTGGTGCAACTGGTGCTGGCGGGGAAGCTCCCAAATTACTTATTCGTGTTTCACCGGAACAAAAAGTCTGGATTGA
CACCTACCAAGAACAATTTGATCAGCCAGATCAGCATTATTTGGTGAAATTCCCGCGAAATAAACGTAGCGAGATTGATT
GCGATATTCTCAGAGCTGAATATTATTACTATCAAATACTCAATGAATTAGGTTTCAACACAATTGAAACAACCCAAATG
CAGCTCATTGAAGGTACAAAATATCCGTCATTGTGGCTTCCAAGATTCGATACAGAATGGTGTGATCAATATTGGCACCG
CTATGGTCTAGAGTCTGTGTATTCTGTACTAAATAAGTCTTCTGGTAGTCATCTTAATCATTTCGAAGTCATTGAAGATC
TATGTAGATTACTCACAAGCATTGACTCAGATTTTGATGTACCACAATTTATTTGTGAGTGGTTACAACGTGACTTACTC
AATATCATTTTTGGTAATTCAGATAACCACGGTCGTAATACATCGTTTATAAAAAAATCTGGAAAAATTTATCTTTCGCC
TATTTATGACTTTGCACCTATGAAAGCCGATCCGGAAGTTGTGACCAGATCGACGACTTGGGGAAGTCCGTACGAGGAAG
GTGGTGAATACCGGTGGGCGCAAATTACACAAAAACTTGCTCCTTGGTGCGATCCCGATTTATCTCTAGCGACATTAAGG
ACTTTGGCGAATAACCTGCTTGGCTTAAAGCAACGATTAGTTGATAAAGGTGTACCCAAACAAATTATTGAAATACCAGC
GCTGTCATTTGATTACATAGAAGCTAAATTGAAAAGATGGGAACTGCTATGA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11620.50 Da
• Isoelectric Point: 9.9701

>AT93355 WP_001101311.1 NZ_CP026125:c1070063-1069755 [Acinetobacter baumannii]
MNVKNQTQDRQQILIDLYKQYLLSEITLGQLLSYLRKNVLGLSQEQYANLVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVSKIIKSNE

Nucleotide

• Length: 309 bp

>AT93355 NZ_CP026125:c1070063-1069755 [Acinetobacter baumannii]
ATGAATGTAAAAAATCAAACCCAAGACCGTCAGCAGATTCTTATAGATTTATATAAACAATATTTGTTGAGTGAGATTAC
TTTGGGGCAATTGCTATCGTATTTACGCAAAAATGTGTTGGGTTTATCGCAAGAACAATATGCTAATTTGGTGGGTATAA
GCCGTCGGACTTTAACGGACATTGAGCAGGATAAAGGTAAACTCACTCAGTCTGTGTTAGATAAAGTGTTTAAACCACTT
GGTTTAAAAGCAGGGCTTGTACCTACGCATGAACATATTGTTAGCAAAATTATAAAGTCAAATGAGTAA

Structures

Toxin

• AlphaFold DB: A0A2I8CRD3