Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 397970..398621 Replicon chromosome
Accession NZ_CP026125
Organism Acinetobacter baumannii strain ABNIH28

Toxin (Protein)


Gene name hicA Uniprot ID A0A2I8CPG2
Locus tag C2U32_RS02095 Protein ID WP_023188274.1
Coordinates 397970..398152 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A2I8CQ49
Locus tag C2U32_RS02100 Protein ID WP_023188275.1
Coordinates 398217..398621 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2U32_RS02045 393230..393895 + 666 WP_023188266.1 stress-responsive nuclear envelope protein -
C2U32_RS02050 393900..394289 + 390 WP_049065468.1 hypothetical protein -
C2U32_RS02055 394291..394659 + 369 WP_049065467.1 hypothetical protein -
C2U32_RS02060 394668..395042 + 375 WP_103270765.1 hypothetical protein -
C2U32_RS02070 395237..395605 + 369 WP_049065464.1 hypothetical protein -
C2U32_RS02075 395607..396005 + 399 WP_049065463.1 hypothetical protein -
C2U32_RS02080 396123..397058 + 936 WP_103270767.1 hypothetical protein -
C2U32_RS02085 397108..397641 + 534 WP_086223776.1 hypothetical protein -
C2U32_RS02095 397970..398152 + 183 WP_023188274.1 type II toxin-antitoxin system HicA family toxin Toxin
C2U32_RS02100 398217..398621 + 405 WP_023188275.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
C2U32_RS02105 398704..399051 + 348 WP_031959349.1 hypothetical protein -
C2U32_RS02110 399138..399320 + 183 Protein_410 hypothetical protein -
C2U32_RS02115 399492..399680 + 189 WP_031959380.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 383325..424799 41474


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6709.82 Da        Isoelectric Point: 10.6249

>T93354 WP_023188274.1 NZ_CP026125:397970-398152 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPNKRGLVTIPHPKKDLPSGTVKSILKQAGLN

Download         Length: 183 bp

>T93354 NZ_CP026125:397970-398152 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGACGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
CAAGCACCCAAACAAAAGGGGATTAGTTACCATCCCACATCCTAAAAAGGATTTACCAAGCGGAACTGTTAAAAGCATTT
TGAAGCAAGCGGGTCTAAATTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14689.74 Da        Isoelectric Point: 4.5000

>AT93354 WP_023188275.1 NZ_CP026125:398217-398621 [Acinetobacter baumannii]
MLYPIAIERGIDTEAFGVTVPDIPGCFSAGDTLGEAIENVKEAISGHLEILAEDGEEIPLASDVSKFIDQEDYRGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT93354 NZ_CP026125:398217-398621 [Acinetobacter baumannii]
ATGTTGTATCCAATTGCTATTGAGAGAGGTATCGACACTGAAGCCTTTGGTGTCACCGTTCCAGATATTCCAGGATGTTT
TAGCGCAGGCGATACATTAGGCGAAGCTATCGAGAACGTTAAAGAGGCAATTTCTGGCCACTTAGAAATTCTTGCTGAAG
ATGGAGAAGAAATTCCATTAGCATCGGATGTCAGTAAGTTTATTGACCAAGAAGATTATAGAGGTATGATCTGGGCAGTT
ACTGAAGTTGATGTCAGCCGTTATTTAGGTAAGCCGGAAAAAATCAATGTAACTTTACCTAGCCGTTTAATTCGGAAGAT
TGATGATAACGTAGGTAAAGATAAAAGATTTAAAACTCGATCAGCATTTTTGGCCGCTGGTGCTGAAAAGCTATTACATG
CTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I8CPG2

Antitoxin

Source ID Structure
AlphaFold DB A0A2I8CQ49

References