Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 3648871..3649542 Replicon chromosome
Accession NZ_CP026124
Organism Achromobacter sp. AONIH1

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag C2U31_RS16770 Protein ID WP_103273794.1
Coordinates 3649237..3649542 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag C2U31_RS16765 Protein ID WP_103273793.1
Coordinates 3648871..3649158 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2U31_RS16745 3644075..3645886 - 1812 WP_199771039.1 dipeptide ABC transporter ATP-binding protein -
C2U31_RS16750 3645938..3646450 - 513 WP_103273790.1 winged helix DNA-binding protein -
C2U31_RS16755 3646567..3648258 - 1692 WP_103273791.1 ATP-binding cassette domain-containing protein -
C2U31_RS16760 3648440..3648793 - 354 WP_103273792.1 hypothetical protein -
C2U31_RS16765 3648871..3649158 - 288 WP_103273793.1 putative addiction module antidote protein Antitoxin
C2U31_RS16770 3649237..3649542 - 306 WP_103273794.1 addiction module protein Toxin
C2U31_RS16775 3649966..3651195 + 1230 WP_103273795.1 acetamidase/formamidase family protein -
C2U31_RS16780 3651207..3651539 + 333 WP_103273796.1 zinc ribbon domain-containing protein -
C2U31_RS16785 3651704..3652117 - 414 WP_103276417.1 copper resistance protein NlpE -
C2U31_RS16790 3652261..3652734 + 474 WP_103273797.1 OsmC family protein -
C2U31_RS16795 3652913..3653359 + 447 WP_103273798.1 carboxymuconolactone decarboxylase family protein -
C2U31_RS16800 3653375..3654304 + 930 WP_103273799.1 sigma-70 family RNA polymerase sigma factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-90)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11551.26 Da        Isoelectric Point: 9.8888

>T93351 WP_103273794.1 NZ_CP026124:c3649542-3649237 [Achromobacter sp. AONIH1]
VKELRSTQAYDDFEARLKDKVGKARIQARIQRLALGNPGRCRHQEKGVSELKIDFGPGYRVYFTERIAGTIVILLAEGDK
STQDADIRMALRLVDKLDWNF

Download         Length: 306 bp

>T93351 NZ_CP026124:c3649542-3649237 [Achromobacter sp. AONIH1]
GTGAAAGAACTCCGCAGCACCCAAGCCTATGATGACTTCGAAGCCCGCCTGAAGGACAAGGTCGGCAAGGCGCGAATACA
AGCACGCATACAGCGACTGGCCCTCGGAAACCCAGGCAGATGCCGGCATCAGGAAAAGGGAGTCTCTGAATTGAAAATTG
ATTTCGGTCCCGGCTATCGGGTGTATTTCACCGAACGCATCGCGGGAACCATCGTCATCCTACTTGCAGAAGGAGATAAA
TCGACCCAGGACGCCGATATCAGGATGGCGCTACGCCTGGTCGACAAACTGGACTGGAATTTCTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10376.15 Da        Isoelectric Point: 9.9223

>AT93351 WP_103273793.1 NZ_CP026124:c3649158-3648871 [Achromobacter sp. AONIH1]
MRKLTTRKYDIAERLKTPEEMALYLDACIAEGDAALIAKALGDIARAKGMTQVARDTGLSRESLYKALSGERAPDFSTIL
KVLRALGLRLHATLA

Download         Length: 288 bp

>AT93351 NZ_CP026124:c3649158-3648871 [Achromobacter sp. AONIH1]
ATGCGCAAACTGACGACACGGAAATACGACATCGCGGAGCGCCTGAAAACGCCCGAGGAAATGGCGCTTTACCTGGACGC
ATGCATCGCCGAAGGCGATGCGGCGCTGATTGCCAAGGCGCTCGGCGATATCGCGCGCGCCAAGGGCATGACCCAGGTCG
CGCGGGACACCGGGCTGTCACGCGAGAGCCTGTATAAAGCGCTGTCCGGGGAGCGCGCCCCCGACTTCAGCACCATTCTC
AAGGTCTTGCGCGCGCTTGGCCTGCGCCTGCATGCCACCCTTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References