Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/PRK09812-MazE
Location 1498397..1498989 Replicon chromosome
Accession NZ_CP026124
Organism Achromobacter sp. AONIH1

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag C2U31_RS06910 Protein ID WP_103272166.1
Coordinates 1498397..1498744 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag C2U31_RS06915 Protein ID WP_103272167.1
Coordinates 1498744..1498989 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2U31_RS06890 1494317..1495150 + 834 WP_103272163.1 AraC family transcriptional regulator -
C2U31_RS06895 1495217..1496251 - 1035 WP_103276291.1 low specificity L-threonine aldolase -
C2U31_RS06900 1496413..1497267 + 855 WP_103272164.1 class II glutamine amidotransferase -
C2U31_RS06905 1497372..1498355 - 984 WP_103272165.1 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase -
C2U31_RS06910 1498397..1498744 - 348 WP_103272166.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
C2U31_RS06915 1498744..1498989 - 246 WP_103272167.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
C2U31_RS06920 1499212..1500342 - 1131 WP_103272168.1 M20 family metallopeptidase -
C2U31_RS06925 1500380..1501285 - 906 WP_103272169.1 prolyl oligopeptidase family serine peptidase -
C2U31_RS06930 1501295..1502305 - 1011 WP_103272170.1 ABC transporter ATP-binding protein -
C2U31_RS06935 1502302..1503285 - 984 WP_103272171.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-113)

Antitoxin

SpoVT-AbrB domain

(6-50)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12720.61 Da        Isoelectric Point: 7.9698

>T93350 WP_103272166.1 NZ_CP026124:c1498744-1498397 [Achromobacter sp. AONIH1]
MAYVPSHGDIVHLQFDPAAGREMTGPHYGLVVSHKEFNQLGLAMICPISQGQATEQRTHGTVVTLMGTGTATTGSIHCHQ
LKSLDWRVRQAKRKESVPAYLVDEVWARLEAIMRP

Download         Length: 348 bp

>T93350 NZ_CP026124:c1498744-1498397 [Achromobacter sp. AONIH1]
ATGGCATACGTGCCCAGCCACGGCGATATCGTGCATCTACAGTTTGATCCCGCTGCCGGCAGGGAAATGACGGGTCCGCA
CTACGGACTAGTCGTCAGCCACAAGGAGTTCAATCAACTTGGACTGGCGATGATCTGTCCGATTTCACAAGGTCAGGCCA
CCGAACAACGCACTCATGGCACGGTGGTCACGCTGATGGGCACGGGGACCGCGACGACGGGCAGCATCCATTGCCATCAA
CTGAAATCACTGGATTGGCGCGTGCGGCAGGCCAAACGAAAAGAGTCAGTGCCCGCGTACCTCGTCGATGAAGTCTGGGC
TCGGCTTGAAGCGATAATGCGTCCTTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9045.37 Da        Isoelectric Point: 8.6193

>AT93350 WP_103272167.1 NZ_CP026124:c1498989-1498744 [Achromobacter sp. AONIH1]
MRQTLRKAGGSLVMTIPKAYIDQNGLREGSQVELHMSGRRLTIEPPARPRYALTDLLAEMPDGLPRADGWDDMPAVGRER
N

Download         Length: 246 bp

>AT93350 NZ_CP026124:c1498989-1498744 [Achromobacter sp. AONIH1]
ATGCGTCAAACTCTACGCAAGGCAGGAGGTTCGCTCGTGATGACCATCCCCAAGGCATACATCGACCAGAACGGGCTGCG
TGAAGGCTCCCAGGTCGAACTCCACATGTCCGGCCGGCGGCTCACTATCGAACCGCCAGCGCGTCCGCGCTATGCGCTCA
CCGACCTCCTGGCTGAAATGCCGGATGGGCTGCCCCGAGCCGACGGCTGGGACGACATGCCCGCTGTCGGACGGGAGCGC
AACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References