Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 3862507..3863135 Replicon chromosome
Accession NZ_CP026115
Organism Pseudomonas putida strain W5

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag C2H86_RS17630 Protein ID WP_159409138.1
Coordinates 3862507..3862692 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag C2H86_RS17635 Protein ID WP_159412950.1
Coordinates 3862713..3863135 (+) Length 141 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2H86_RS17615 3858412..3859527 - 1116 WP_159409135.1 succinylglutamate desuccinylase/aspartoacylase family protein -
C2H86_RS17620 3859626..3861284 - 1659 WP_159409136.1 ATP-dependent DNA ligase -
C2H86_RS17625 3861281..3862297 - 1017 WP_159409137.1 ligase-associated DNA damage response exonuclease -
C2H86_RS17630 3862507..3862692 + 186 WP_159409138.1 type II toxin-antitoxin system HicA family toxin Toxin
C2H86_RS17635 3862713..3863135 + 423 WP_159412950.1 helix-turn-helix domain-containing protein Antitoxin
C2H86_RS17640 3863182..3865623 - 2442 WP_159409139.1 penicillin acylase family protein -
C2H86_RS17645 3865770..3865970 - 201 WP_023379046.1 SEC-C domain-containing protein -
C2H86_RS17650 3865978..3866454 - 477 WP_159409140.1 LEA type 2 family protein -
C2H86_RS17655 3866457..3866933 - 477 WP_159409141.1 YchJ family protein -
C2H86_RS17660 3866936..3867430 - 495 WP_159409142.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3853805..3863135 9330


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-58)

Antitoxin

Cro/C1-type helix-turn-helix domain

(82-112)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 7010.06 Da        Isoelectric Point: 10.9847

>T93342 WP_159409138.1 NZ_CP026115:3862507-3862692 [Pseudomonas putida]
MKYSEFRRWLRARGATFVPAKGSHFKVYLGNRQTIFPDHGAKEISEGLRRKILSDLGLSES

Download         Length: 186 bp

>T93342 NZ_CP026115:3862507-3862692 [Pseudomonas putida]
ATGAAATACAGTGAATTTCGCCGATGGCTTCGTGCCCGAGGTGCTACGTTCGTTCCGGCCAAAGGCAGCCATTTCAAGGT
TTACCTCGGTAATCGCCAGACAATTTTCCCGGACCATGGTGCCAAAGAAATTAGCGAAGGGCTCAGAAGAAAGATTCTTA
GCGACCTGGGCCTGAGCGAAAGTTGA

Antitoxin


Download         Length: 141 a.a.        Molecular weight: 15515.89 Da        Isoelectric Point: 4.9560

>AT93342 WP_159412950.1 NZ_CP026115:3862713-3863135 [Pseudomonas putida]
IFDYPVIIHREAGSVWISCPDVPEMSSAGDTEEEALFDAVDAMESALSFYVDQKIAIPLPAMRSADQPVVRLPALTAAKA
ALWNTMIEQKVSKTEMARRLGVNRPQVDRLVDLLHRSKIEQVEHALHVLGQRIELAVVTA

Download         Length: 423 bp

>AT93342 NZ_CP026115:3862713-3863135 [Pseudomonas putida]
ATCTTCGACTATCCAGTAATCATTCATCGGGAGGCGGGCAGTGTCTGGATCAGTTGCCCGGATGTGCCTGAGATGTCCAG
TGCAGGCGATACCGAGGAAGAAGCCCTGTTCGATGCTGTGGACGCCATGGAGTCCGCGCTTTCGTTCTATGTTGACCAGA
AGATTGCGATACCGCTGCCTGCAATGAGATCGGCTGATCAGCCTGTCGTACGTTTGCCGGCTCTGACGGCGGCGAAGGCA
GCTCTCTGGAACACCATGATTGAACAGAAAGTGAGCAAAACAGAGATGGCACGGCGGCTGGGCGTCAATCGTCCTCAGGT
CGATCGCCTGGTGGATCTGTTGCATCGTTCCAAGATTGAGCAGGTCGAGCATGCATTGCATGTGCTCGGTCAGCGAATCG
AACTCGCTGTCGTCACTGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References