Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-DUF971
Location 1036949..1037537 Replicon chromosome
Accession NZ_CP026115
Organism Pseudomonas putida strain W5

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag C2H86_RS04600 Protein ID WP_159411608.1
Coordinates 1036949..1037251 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag C2H86_RS04605 Protein ID WP_159411609.1
Coordinates 1037244..1037537 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2H86_RS04580 1033011..1033904 - 894 WP_159411604.1 LysR family transcriptional regulator -
C2H86_RS04585 1034011..1035180 + 1170 WP_159411605.1 MFS transporter -
C2H86_RS04590 1035293..1036219 - 927 WP_159411606.1 DMT family transporter -
C2H86_RS04595 1036326..1036721 - 396 WP_159411607.1 transcriptional regulator -
C2H86_RS04600 1036949..1037251 + 303 WP_159411608.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C2H86_RS04605 1037244..1037537 + 294 WP_159411609.1 putative addiction module antidote protein Antitoxin
C2H86_RS04610 1037542..1038345 - 804 WP_159411610.1 LuxR family transcriptional regulator -
C2H86_RS04615 1038432..1039664 - 1233 WP_159411611.1 ethanolamine utilization protein EutH -
C2H86_RS04620 1039762..1040526 - 765 WP_159411612.1 SDR family oxidoreductase -
C2H86_RS04625 1040683..1040955 + 273 WP_159411613.1 hypothetical protein -
C2H86_RS04630 1041083..1042444 - 1362 WP_110636930.1 DEAD/DEAH box helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-90)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11435.10 Da        Isoelectric Point: 10.1834

>T93338 WP_159411608.1 NZ_CP026115:1036949-1037251 [Pseudomonas putida]
MKIFESSSFRKWVVGLRDANARDRIISRITRLVEGMPGDVSPVGHGISELRIHYGPGYRVYFHQSGDTWVILLCGGDKGS
QPRDIKAAYQILRTWRMQND

Download         Length: 303 bp

>T93338 NZ_CP026115:1036949-1037251 [Pseudomonas putida]
ATGAAAATATTCGAATCCAGCAGTTTCAGAAAATGGGTGGTCGGGCTTCGAGATGCAAACGCGAGGGACAGGATCATCTC
CCGCATCACCCGACTCGTTGAAGGTATGCCAGGTGATGTCTCACCCGTAGGCCATGGCATCAGTGAGCTCAGGATTCACT
ATGGTCCGGGTTATCGGGTGTACTTTCACCAATCGGGCGATACGTGGGTGATTCTGCTCTGTGGTGGTGACAAAGGTAGC
CAACCGCGAGATATCAAGGCTGCCTACCAGATTCTGCGTACGTGGAGGATGCAAAATGACTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10548.08 Da        Isoelectric Point: 6.4810

>AT93338 WP_159411609.1 NZ_CP026115:1037244-1037537 [Pseudomonas putida]
MTEKFFEFDPANYLTTPEAIAHFMTDALETGDAGYVAKAVGVVARAKGMSELAKETGLSREQLYRSFSEHGNPTLKSFLA
VMKALGIDMAAKPHLAH

Download         Length: 294 bp

>AT93338 NZ_CP026115:1037244-1037537 [Pseudomonas putida]
ATGACTGAAAAATTCTTCGAATTCGATCCTGCAAATTACCTCACCACACCAGAGGCCATCGCGCACTTCATGACCGATGC
GCTGGAAACAGGTGACGCTGGCTATGTTGCAAAAGCCGTCGGCGTCGTGGCACGGGCCAAGGGAATGAGTGAGCTGGCAA
AAGAGACCGGCCTTTCGCGTGAGCAGCTTTATCGCTCATTCAGCGAGCATGGCAACCCTACTCTCAAATCCTTTCTGGCA
GTAATGAAGGCACTGGGCATAGACATGGCGGCCAAGCCTCACCTTGCTCACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References