Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ParST/RES-TIGR02293
Location 399422..400431 Replicon chromosome
Accession NZ_CP026114
Organism Paraburkholderia terrae strain DSM 17804

Toxin (Protein)


Gene name ParT Uniprot ID A0A2I8F479
Locus tag C2L65_RS43610 Protein ID WP_042305802.1
Coordinates 399955..400431 (+) Length 159 a.a.

Antitoxin (Protein)


Gene name ParS Uniprot ID A0A2I8F4P3
Locus tag C2L65_RS43605 Protein ID WP_052426841.1
Coordinates 399422..399958 (+) Length 179 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2L65_RS43580 395573..395920 - 348 WP_042305805.1 hypothetical protein -
C2L65_RS43585 396057..396377 - 321 WP_042305804.1 CcdB family protein -
C2L65_RS43590 396377..396643 - 267 WP_081920823.1 type II toxin-antitoxin system CcdA family antitoxin -
C2L65_RS43595 396942..397222 + 281 Protein_352 hypothetical protein -
C2L65_RS43600 397239..398756 - 1518 WP_042305896.1 sensor domain-containing diguanylate cyclase -
C2L65_RS43605 399422..399958 + 537 WP_052426841.1 DUF2384 domain-containing protein Antitoxin
C2L65_RS43610 399955..400431 + 477 WP_042305802.1 RES family NAD+ phosphorylase Toxin
C2L65_RS43615 400738..401121 - 384 WP_081920809.1 SET domain-containing protein-lysine N-methyltransferase -
C2L65_RS43625 401773..403224 + 1452 WP_052426826.1 toll/interleukin-1 receptor domain-containing protein -
C2L65_RS43635 403565..404653 - 1089 WP_042305799.1 glycosyltransferase family 4 protein -
C2L65_RS43640 404811..405203 + 393 WP_103254689.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(5-153)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(126-175)


Sequences

Toxin        


Download         Length: 159 a.a.        Molecular weight: 17102.64 Da        Isoelectric Point: 7.8490

>T93336 WP_042305802.1 NZ_CP026114:399955-400431 [Paraburkholderia terrae]
VTVAVWRIATEAPNYPADDLSGAGAKVTGGRWNRRGTPVLYCASTIALACLETVVHIRAAGLPLNRYLVRLDVPDNVWQA
ATVFTNISAPIGWDAIPPGMTSLDTGEKWIYNAATALLLVPSVIVPEETNVLINPAHPDAAGIRAQKVRRWTYDQRMG

Download         Length: 477 bp

>T93336 NZ_CP026114:399955-400431 [Paraburkholderia terrae]
GTGACGGTCGCGGTCTGGCGGATCGCGACCGAAGCGCCCAACTACCCCGCAGACGATCTTTCCGGTGCCGGCGCGAAGGT
GACGGGTGGCCGGTGGAACCGGCGCGGAACGCCGGTTTTGTACTGTGCGTCGACCATCGCCCTGGCCTGTCTGGAAACCG
TGGTTCACATTCGCGCGGCGGGATTGCCGCTGAACCGCTACCTCGTTCGTCTGGACGTGCCCGACAACGTCTGGCAGGCC
GCGACGGTTTTCACGAACATCTCAGCGCCCATCGGGTGGGACGCAATCCCCCCCGGTATGACGAGCCTGGATACAGGTGA
GAAATGGATCTATAACGCCGCCACCGCCCTGCTTCTTGTGCCGTCCGTCATCGTCCCGGAGGAGACGAACGTCCTCATCA
ACCCGGCACATCCGGATGCAGCGGGCATTCGTGCGCAGAAAGTGCGGCGTTGGACCTACGATCAGCGAATGGGTTAA

Antitoxin


Download         Length: 179 a.a.        Molecular weight: 19187.98 Da        Isoelectric Point: 10.3478

>AT93336 WP_052426841.1 NZ_CP026114:399422-399958 [Paraburkholderia terrae]
VNAPATSARRPARKAAVRLPAKPAAPSRAAKVHATKINDYLTLYHAPPLERISFIKHGVDAHDVYVLARNMGTSQDNLMV
TLGLPRSTIIRKAKGKARLSAEQSERVIGMARLVGQVEAMVAESGDPAGFDAAHWVNEWLDQPNPALDQRRPAEFMDTVA
GQEFVAALLAKAQSGAYA

Download         Length: 537 bp

>AT93336 NZ_CP026114:399422-399958 [Paraburkholderia terrae]
GTGAACGCGCCCGCCACCTCCGCCCGTCGCCCGGCCCGCAAGGCTGCAGTTCGTCTCCCGGCAAAACCCGCCGCGCCGTC
GCGGGCCGCCAAAGTGCATGCGACGAAGATCAACGACTACCTCACCCTCTATCACGCGCCTCCGCTCGAGCGCATCAGCT
TCATCAAGCACGGTGTGGATGCCCACGACGTGTACGTTCTTGCGCGCAACATGGGAACCTCGCAGGATAATCTGATGGTG
ACCCTGGGGTTGCCGCGCTCGACCATCATCCGTAAGGCCAAGGGGAAGGCGCGCCTGTCTGCGGAGCAGAGCGAACGGGT
GATCGGTATGGCAAGGCTGGTCGGCCAGGTCGAAGCGATGGTCGCGGAATCCGGTGATCCGGCAGGCTTCGACGCTGCCC
ACTGGGTGAACGAATGGCTGGACCAGCCCAACCCGGCACTGGATCAACGCCGTCCTGCCGAGTTCATGGATACGGTCGCG
GGACAGGAATTTGTCGCTGCCCTGCTGGCGAAGGCACAGAGCGGAGCGTACGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I8F479

Antitoxin

Source ID Structure
AlphaFold DB A0A2I8F4P3

References