Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 2904287..2906037 Replicon chromosome
Accession NZ_CP026112
Organism Paraburkholderia terrae strain DSM 17804

Toxin (Protein)


Gene name doc Uniprot ID A0A2I8EXT3
Locus tag C2L65_RS29285 Protein ID WP_042304478.1
Coordinates 2905144..2906037 (-) Length 298 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A2I8EVE8
Locus tag C2L65_RS29280 Protein ID WP_042304479.1
Coordinates 2904287..2905147 (-) Length 287 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2L65_RS29260 2899484..2900980 - 1497 WP_042304483.1 aldehyde dehydrogenase -
C2L65_RS29265 2901007..2901837 - 831 WP_042304482.1 aspartate dehydrogenase -
C2L65_RS29270 2901830..2903488 - 1659 WP_042304481.1 thiamine pyrophosphate-binding protein -
C2L65_RS29275 2903481..2904287 - 807 WP_042304480.1 SDR family oxidoreductase -
C2L65_RS29280 2904287..2905147 - 861 WP_042304479.1 IclR family transcriptional regulator Antitoxin
C2L65_RS29285 2905144..2906037 - 894 WP_042304478.1 alpha/beta fold hydrolase Toxin
C2L65_RS29290 2906069..2906608 - 540 WP_035999007.1 cupin domain-containing protein -
C2L65_RS29295 2906644..2907402 - 759 WP_042304477.1 SDR family oxidoreductase -
C2L65_RS29300 2907395..2908483 - 1089 WP_042304476.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
C2L65_RS29305 2908526..2908837 - 312 WP_042304475.1 hypothetical protein -
C2L65_RS29310 2908839..2909156 - 318 WP_007587796.1 non-heme iron oxygenase ferredoxin subunit -
C2L65_RS29315 2909597..2910670 + 1074 WP_042304474.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(50-276)

Antitoxin

Transcription regulator IclR, C-terminal

(144-267)


Sequences

Toxin        


Download         Length: 298 a.a.        Molecular weight: 31179.09 Da        Isoelectric Point: 6.4950

>T93335 WP_042304478.1 NZ_CP026112:c2906037-2905144 [Paraburkholderia terrae]
MSAALPVTADRNATLETRLSHFPAQRISIAPQRAMGYRAAGAGHADALPLVLLHGIGSGAASWVQQFETLGTTRRVFAWD
APGYGESTPVVSASPEANEYASALNAWLDALDIERCVLVGHSLGAIIAGSFAASHAERVAGLLLISPAAGYGAASEEVRA
SKRDSRLAMLAELGPQGLAEKRSANMLSPHADDASREWVRWNMSRILPNGYAQATHLLANADLASDVAKINGSIAVAVGA
EDSITPPSSCERIAQAARTRLQIIPRAGHAGYIEAGNEYTALIDAFCRASDGQWSKA

Download         Length: 894 bp

>T93335 NZ_CP026112:c2906037-2905144 [Paraburkholderia terrae]
ATGTCCGCAGCCTTGCCCGTCACCGCCGATCGAAACGCCACGCTGGAAACGCGCCTCTCGCACTTCCCGGCACAGCGGAT
CTCGATTGCGCCGCAACGCGCGATGGGTTATCGCGCAGCGGGCGCCGGCCATGCCGATGCGTTGCCGCTCGTGCTGTTGC
ACGGCATTGGATCGGGCGCGGCTTCGTGGGTGCAACAGTTCGAAACGCTCGGCACGACACGCCGCGTGTTCGCGTGGGAC
GCGCCGGGCTACGGCGAATCGACGCCAGTCGTGTCGGCATCGCCTGAAGCAAATGAATATGCGAGCGCGCTCAACGCATG
GCTCGACGCGCTCGACATAGAACGTTGCGTACTGGTCGGTCATTCGCTCGGCGCGATCATCGCGGGTTCGTTCGCAGCGT
CGCATGCGGAACGTGTTGCCGGTCTGTTGCTGATTTCGCCCGCAGCAGGCTACGGCGCGGCGTCCGAAGAAGTGCGCGCA
TCGAAACGCGACAGCCGCCTCGCGATGCTTGCCGAACTCGGCCCGCAAGGACTCGCGGAAAAACGCAGCGCCAACATGCT
CTCGCCGCACGCCGACGACGCATCGCGCGAGTGGGTTCGCTGGAACATGTCGCGCATCCTGCCGAACGGTTACGCGCAGG
CGACGCATCTGCTCGCCAACGCGGACCTCGCCAGCGATGTCGCGAAGATCAACGGCAGTATCGCCGTCGCGGTCGGCGCG
GAAGACTCGATCACGCCGCCGTCGTCATGCGAGCGGATCGCACAGGCGGCGCGTACGCGTTTGCAGATCATCCCGCGCGC
GGGTCACGCGGGCTATATCGAAGCGGGCAATGAATACACCGCGCTCATCGACGCATTCTGCCGCGCGAGCGACGGCCAAT
GGAGTAAAGCATGA

Antitoxin


Download         Length: 287 a.a.        Molecular weight: 31510.92 Da        Isoelectric Point: 6.5092

>AT93335 WP_042304479.1 NZ_CP026112:c2905147-2904287 [Paraburkholderia terrae]
MTPELTGTAPEAEDDRNDANYRVPGLERGLRILTEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADRDRN
YRLGVAVLRLGFEYLSSLELTDLGLPLIEGLRDATGLTTHIVIRDGRDVVFVAKAQSHAPVFSSVKVNVGTRLPAHATTH
GHVLMGDLSLDELRALYPEKTLERFTKHTPATVDELYERVKDDAVRGFAISESSFENGISVISAPVRNDTGRIAAVITTT
IPRPQIDATLLDGGLIDKVRSAAEQLSLRLNYRPSAESRYMKALGL

Download         Length: 861 bp

>AT93335 NZ_CP026112:c2905147-2904287 [Paraburkholderia terrae]
ATGACCCCCGAATTGACGGGCACTGCGCCTGAAGCAGAAGACGACCGCAACGACGCGAACTACCGCGTGCCCGGTCTCGA
ACGTGGCTTGCGCATTCTCACGGAGTTTTCGCCGCGCGAGCCGGTGCTCGGCGCGCCCGAGTTGTCGAAGCGCCTCGGCA
TTCCCCGCACGACGGTGTTCCGTCTGCTGCAGACGCTCGAATCGCTCGGCTTTCTGGAGCGCGCGGATCGCGACCGCAAC
TATCGGCTGGGCGTCGCGGTGCTGCGCCTCGGCTTCGAATATCTCAGCTCGCTCGAACTCACCGATCTCGGCTTGCCGTT
GATCGAAGGCTTGCGCGATGCAACGGGCCTGACCACGCACATCGTGATCCGCGATGGCCGCGACGTGGTGTTCGTCGCGA
AGGCGCAGAGCCACGCGCCCGTGTTCAGCTCGGTGAAGGTGAACGTCGGCACGCGGCTACCCGCGCATGCGACGACGCAT
GGTCATGTGCTGATGGGCGATCTCTCGCTCGACGAACTGCGCGCGCTGTATCCGGAGAAGACGCTTGAACGTTTCACGAA
ACACACGCCCGCCACCGTCGACGAACTGTACGAGCGCGTGAAGGACGACGCGGTGCGCGGTTTCGCAATCAGCGAATCGT
CCTTTGAAAACGGCATATCCGTGATCAGCGCGCCCGTGCGCAACGACACGGGCCGCATCGCCGCTGTCATCACCACGACG
ATTCCGCGTCCGCAGATCGACGCGACGCTGCTCGATGGCGGCCTGATCGACAAGGTGCGCAGCGCGGCGGAGCAACTGTC
GCTGCGGCTGAACTATCGGCCGTCGGCGGAAAGCAGGTACATGAAGGCATTGGGGCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I8EXT3

Antitoxin

Source ID Structure
AlphaFold DB A0A2I8EVE8

References