Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3497164..3497798 Replicon chromosome
Accession NZ_CP026111
Organism Paraburkholderia terrae strain DSM 17804

Toxin (Protein)


Gene name hicA Uniprot ID A0A2I8EMQ7
Locus tag C2L65_RS15580 Protein ID WP_042305133.1
Coordinates 3497164..3497346 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A2I8EMR0
Locus tag C2L65_RS15585 Protein ID WP_042305132.1
Coordinates 3497397..3497798 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2L65_RS15570 3493966..3496095 - 2130 WP_042305135.1 tetratricopeptide repeat protein -
C2L65_RS15575 3496130..3496819 - 690 WP_042305134.1 hypothetical protein -
C2L65_RS15580 3497164..3497346 + 183 WP_042305133.1 type II toxin-antitoxin system HicA family toxin Toxin
C2L65_RS15585 3497397..3497798 + 402 WP_042305132.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
C2L65_RS15590 3498199..3498807 - 609 WP_042305131.1 hypothetical protein -
C2L65_RS15605 3499872..3500804 + 933 WP_042305129.1 cytochrome c5 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6662.83 Da        Isoelectric Point: 11.1475

>T93333 WP_042305133.1 NZ_CP026111:3497164-3497346 [Paraburkholderia terrae]
MNSSKLIRMLEAAGWREVRVTGSHHHFKHPDRKGLVTVPHPKKDLPLGTVKSILKAAGLD

Download         Length: 183 bp

>T93333 NZ_CP026111:3497164-3497346 [Paraburkholderia terrae]
ATGAACTCATCGAAGCTGATCCGGATGCTCGAAGCAGCGGGTTGGAGGGAGGTGAGGGTGACGGGAAGTCATCACCACTT
CAAACACCCCGATAGGAAGGGCCTTGTGACGGTGCCTCATCCGAAAAAGGATCTGCCGCTCGGGACCGTAAAGAGCATCC
TGAAGGCCGCCGGTCTTGACTGA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14578.50 Da        Isoelectric Point: 4.9852

>AT93333 WP_042305132.1 NZ_CP026111:3497397-3497798 [Paraburkholderia terrae]
MEFPIAVHKDDGSVYGVTVPDIPGVHSWGDTIDEAIRNAREAIVGHVSTLVELGEDVGFTCSTVEELVGKKEFKGAVWAL
VDVDLSKLDSKPERINISLPRFVLHKIDAYVESRHETRSGFLARAALEALAHN

Download         Length: 402 bp

>AT93333 NZ_CP026111:3497397-3497798 [Paraburkholderia terrae]
ATGGAATTTCCCATCGCAGTTCATAAGGACGATGGGAGCGTCTACGGAGTGACTGTTCCGGATATTCCGGGCGTCCACTC
ATGGGGCGACACCATCGATGAAGCGATCCGCAATGCAAGAGAAGCAATCGTAGGCCACGTCTCAACCTTGGTCGAACTCG
GCGAAGATGTCGGTTTCACCTGTTCCACTGTGGAAGAGCTCGTTGGCAAGAAAGAGTTCAAAGGGGCGGTTTGGGCGCTG
GTGGATGTCGATCTGTCGAAGCTTGACTCAAAGCCTGAGCGAATCAACATCAGTCTTCCTCGCTTTGTTTTACATAAGAT
CGACGCGTACGTCGAATCACGTCATGAAACGAGGAGCGGCTTCCTCGCGCGTGCAGCATTGGAAGCGTTGGCGCATAACT
AA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I8EMQ7

Antitoxin

Source ID Structure
AlphaFold DB A0A2I8EMR0

References