Detailed information of TA system TA093332

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1-StbC
• Location: 1529211..1529871
• Replicon: chromosome
• Accession: NZ_CP026111
• Organism: Paraburkholderia terrae strain DSM 17804

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: C2L65_RS06855
• Protein ID: WP_081921406.1
• Coordinates: 1529443..1529871 (+)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A2I8ENG4
• Locus tag: C2L65_RS06850
• Protein ID: WP_042314804.1
• Coordinates: 1529211..1529456 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C2L65_RS06825	1524803..1525315	-	513	WP_042314787.1	Spy/CpxP family protein refolding chaperone	-
C2L65_RS06830	1525468..1526352	+	885	WP_042314786.1	LysR family transcriptional regulator	-
C2L65_RS06835	1526490..1526954	+	465	WP_042314785.1	Lrp/AsnC family transcriptional regulator	-
C2L65_RS06840	1527161..1528258	+	1098	WP_042314784.1	saccharopine dehydrogenase NADP-binding domain-containing protein	-
C2L65_RS06845	1528421..1529041	-	621	WP_042314783.1	ATP-binding protein	-
C2L65_RS06850	1529211..1529456	+	246	WP_042314804.1	DNA-binding protein	Antitoxin
C2L65_RS06855	1529443..1529871	+	429	WP_081921406.1	type II toxin-antitoxin system VapC family toxin	Toxin
C2L65_RS06860	1529961..1530434	+	474	WP_081921404.1	hypothetical protein	-
C2L65_RS06865	1530639..1531616	+	978	WP_042314781.1	magnesium/cobalt transporter CorA	-
C2L65_RS06870	1531659..1532297	-	639	WP_042314780.1	LysE family translocator	-
C2L65_RS06875	1532847..1533803	+	957	WP_042314779.1	sugar ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-122)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 15736.97 Da
• Isoelectric Point: 8.5621

>T93332 WP_081921406.1 NZ_CP026111:1529443-1529871 [Paraburkholderia terrae]
VYLVDTNVISEMRKSSRANPGVQAFFETAKKGGHRLYLSVVTVGELRRGVDLIRHRGDKFQALRLEGWLDTIMSSFSSQI
LNVGTDVAQTWGHLRVPDPEHSLDKLIAATALIYNLTVVTRNVADFDGTGARVLNPFQLLDA

Nucleotide

• Length: 429 bp

>T93332 NZ_CP026111:1529443-1529871 [Paraburkholderia terrae]
GTGTATTTGGTTGATACCAATGTAATCAGCGAAATGCGCAAGAGCAGCCGCGCCAATCCAGGCGTGCAGGCTTTTTTCGA
AACGGCGAAGAAAGGCGGGCATCGCCTGTATCTGTCGGTGGTGACGGTCGGCGAGTTGCGGCGCGGCGTCGACCTGATCC
GGCATCGGGGCGACAAGTTCCAGGCGTTGCGCCTGGAAGGCTGGCTCGACACGATCATGAGTTCGTTCAGCAGCCAGATC
CTGAATGTCGGCACCGACGTCGCGCAGACGTGGGGCCATCTGCGCGTGCCGGACCCCGAGCACTCGCTGGACAAGCTGAT
CGCGGCGACGGCCCTGATCTACAACCTGACTGTCGTGACGCGCAACGTGGCAGACTTCGATGGCACGGGCGCACGGGTGC
TGAATCCGTTCCAGCTTCTTGACGCATGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8880.90 Da
• Isoelectric Point: 4.3046

>AT93332 WP_042314804.1 NZ_CP026111:1529211-1529456 [Paraburkholderia terrae]
MANLLVRNLDDALVQNLREQAAAHGRSVEAEHREILAQALFQPKKLSFAELLMSMPDVGDDADFERRNDVTDDSGGPGVF
G

Nucleotide

• Length: 246 bp

>AT93332 NZ_CP026111:1529211-1529456 [Paraburkholderia terrae]
ATGGCAAATCTTTTGGTCCGAAATCTGGACGATGCGTTGGTGCAGAACCTGCGTGAGCAGGCCGCGGCTCACGGGCGCAG
CGTCGAAGCAGAGCATCGGGAAATCCTGGCGCAGGCGCTCTTTCAGCCCAAGAAGCTCAGCTTTGCGGAATTGCTGATGA
GCATGCCCGACGTCGGCGACGACGCCGACTTCGAGCGCCGCAATGACGTCACTGACGATAGCGGGGGACCGGGTGTATTT
GGTTGA

Structures

Antitoxin

• AlphaFold DB: A0A2I8ENG4