Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1211917..1212436 Replicon chromosome
Accession NZ_CP026111
Organism Paraburkholderia terrae strain DSM 17804

Toxin (Protein)


Gene name relE Uniprot ID A0A2I8EI77
Locus tag C2L65_RS05430 Protein ID WP_042314621.1
Coordinates 1212146..1212436 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A244DDI0
Locus tag C2L65_RS05425 Protein ID WP_007585570.1
Coordinates 1211917..1212159 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2L65_RS05405 1207100..1208014 - 915 WP_042314618.1 ABC transporter permease -
C2L65_RS05410 1208054..1208878 - 825 WP_042314619.1 ABC transporter permease -
C2L65_RS05415 1208875..1209921 - 1047 WP_042314620.1 ABC transporter substrate-binding protein -
C2L65_RS05420 1209965..1211038 - 1074 WP_042314643.1 LacI family DNA-binding transcriptional regulator -
C2L65_RS05425 1211917..1212159 + 243 WP_007585570.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
C2L65_RS05430 1212146..1212436 + 291 WP_042314621.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C2L65_RS05435 1212551..1213171 + 621 WP_042314622.1 glutathione S-transferase -
C2L65_RS05445 1213389..1213580 + 192 WP_007585578.1 hypothetical protein -
C2L65_RS05450 1213708..1215111 + 1404 WP_042314624.1 FAD-containing oxidoreductase -
C2L65_RS05455 1215123..1215455 + 333 WP_042314625.1 cupin domain-containing protein -
C2L65_RS05460 1215597..1216172 + 576 WP_042314626.1 DUF1211 domain-containing protein -
C2L65_RS05465 1216176..1216964 + 789 WP_042314627.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(8-71)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11009.90 Da        Isoelectric Point: 10.5985

>T93331 WP_042314621.1 NZ_CP026111:1212146-1212436 [Paraburkholderia terrae]
MTIYKLQFLESAQKEWSKLDNTVRSQLKRKLAERLENPRVESARLSTMPDCYKIKLAASGYRLVYQVVDRTVTVTVISVG
KRERSAVYAAAIARLM

Download         Length: 291 bp

>T93331 NZ_CP026111:1212146-1212436 [Paraburkholderia terrae]
TTGACGATCTATAAACTGCAGTTTCTTGAATCTGCTCAAAAGGAATGGAGCAAGCTCGATAACACGGTGCGCTCACAGCT
AAAACGCAAGCTGGCCGAACGGCTGGAGAACCCGCGCGTTGAGTCGGCAAGGCTGAGCACGATGCCTGACTGCTACAAAA
TCAAGCTTGCTGCCTCGGGTTACAGACTGGTGTATCAAGTTGTGGATCGTACCGTGACGGTCACGGTGATTTCCGTTGGC
AAGCGCGAAAGAAGCGCAGTCTATGCTGCAGCAATTGCGCGCCTGATGTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8657.90 Da        Isoelectric Point: 4.1954

>AT93331 WP_007585570.1 NZ_CP026111:1211917-1212159 [Paraburkholderia terrae]
MESILARTSIGISELKVNPTAAIEQADGPVAVLNRNKPVAYLIPAAEWEAICERLEDIELAEIVRARSGEKAVSVNLDDL

Download         Length: 243 bp

>AT93331 NZ_CP026111:1211917-1212159 [Paraburkholderia terrae]
ATGGAAAGCATTCTTGCACGCACTTCGATTGGCATCAGCGAGCTCAAGGTTAATCCCACGGCAGCAATTGAGCAGGCAGA
CGGTCCGGTCGCGGTGCTGAATCGAAACAAGCCGGTCGCGTACCTGATCCCTGCGGCCGAATGGGAAGCGATTTGCGAGC
GACTCGAAGATATCGAGCTGGCCGAGATCGTCAGGGCGCGAAGCGGCGAGAAAGCCGTGAGCGTAAATCTTGACGATCTA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I8EI77

Antitoxin

Source ID Structure
AlphaFold DB A0A244DDI0

References