Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 690566..691104 Replicon chromosome
Accession NZ_CP026109
Organism Paraburkholderia hospita strain DSM 17164

Toxin (Protein)


Gene name parE Uniprot ID A0A244DYF7
Locus tag C2L64_RS52315 Protein ID WP_009771251.1
Coordinates 690566..690865 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A7Z7BL02
Locus tag C2L64_RS52320 Protein ID WP_007738653.1
Coordinates 690862..691104 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2L64_RS52300 685810..686982 - 1173 WP_086915035.1 L-rhamnonate dehydratase -
C2L64_RS52305 687047..688093 - 1047 WP_086915036.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
C2L64_RS52310 688266..689219 + 954 WP_086915037.1 LysR family transcriptional regulator -
C2L64_RS52315 690566..690865 - 300 WP_009771251.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C2L64_RS52320 690862..691104 - 243 WP_007738653.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
C2L64_RS52325 691216..691596 - 381 WP_090836750.1 hypothetical protein -
C2L64_RS52330 691600..692841 - 1242 WP_090836753.1 cystathionine gamma-synthase family protein -
C2L64_RS52340 693854..694186 - 333 WP_086915040.1 killer protein -
C2L64_RS52345 694197..694649 - 453 WP_086915041.1 hypothetical protein -
C2L64_RS52350 694649..695356 - 708 WP_086915042.1 StbB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 662286..711181 48895


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11372.80 Da        Isoelectric Point: 5.0701

>T93330 WP_009771251.1 NZ_CP026109:c690865-690566 [Paraburkholderia hospita]
VKEFVLSPAAELDLDDIWDYSAENWGIRQAERYIRMIQDTIVGLTDGTQPSQAASHVRPGYRSVLVGTHILFFKETDNLI
DVIRILHQRMDPSQHLSEH

Download         Length: 300 bp

>T93330 NZ_CP026109:c690865-690566 [Paraburkholderia hospita]
GTGAAGGAATTTGTTCTCTCGCCAGCGGCCGAGCTGGATCTCGATGATATCTGGGACTATTCGGCGGAAAACTGGGGGAT
ACGGCAGGCGGAGCGTTATATCCGCATGATCCAGGACACGATCGTTGGATTGACTGATGGTACACAGCCGAGTCAGGCCG
CCTCCCACGTTCGGCCTGGCTACCGCAGTGTGCTGGTCGGAACTCACATTCTGTTTTTCAAAGAGACCGACAACCTTATC
GACGTTATCCGGATTCTTCATCAGCGGATGGATCCTTCTCAACACCTGAGCGAGCACTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8970.06 Da        Isoelectric Point: 8.6582

>AT93330 WP_007738653.1 NZ_CP026109:c691104-690862 [Paraburkholderia hospita]
MGKNTSVSLGDHFAEFVEDRVRAGRYNTASDVVRAGLRLLEEQEAKLDALRVELEKGERSGPSRPFDFDAFLARKRKSAT

Download         Length: 243 bp

>AT93330 NZ_CP026109:c691104-690862 [Paraburkholderia hospita]
ATGGGCAAGAACACATCCGTTTCGCTCGGCGACCACTTCGCCGAATTTGTCGAAGATCGCGTGCGCGCCGGGCGCTACAA
CACGGCGAGCGACGTGGTTCGAGCTGGCCTGCGTTTGCTAGAGGAACAGGAAGCAAAACTCGATGCCCTGCGCGTCGAGC
TGGAGAAGGGCGAGCGCTCGGGCCCATCCAGGCCATTTGACTTCGACGCGTTTCTCGCACGCAAGAGGAAGTCCGCGACG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A244DYF7

Antitoxin

Source ID Structure
AlphaFold DB A0A7Z7BL02

References