Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazE-MazF
Location 519332..519894 Replicon chromosome
Accession NZ_CP026108
Organism Paraburkholderia hospita strain DSM 17164

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag C2L64_RS46725 Protein ID WP_103154102.1
Coordinates 519332..519580 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag C2L64_RS46730 Protein ID WP_103154103.1
Coordinates 519574..519894 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2L64_RS46700 515468..516190 - 723 Protein_460 IS6 family transposase -
C2L64_RS46705 516223..516483 - 261 WP_158660618.1 hypothetical protein -
C2L64_RS46710 516546..517004 - 459 WP_158660619.1 hypothetical protein -
C2L64_RS46715 517123..518046 - 924 WP_103154100.1 site-specific integrase -
C2L64_RS46720 518565..519224 + 660 WP_103154101.1 tyrosine-type recombinase/integrase -
C2L64_RS46725 519332..519580 + 249 WP_103154102.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Toxin
C2L64_RS46730 519574..519894 + 321 WP_103154103.1 type II toxin-antitoxin system PemK/MazF family toxin Antitoxin
C2L64_RS46735 520191..520514 + 324 WP_158660620.1 hypothetical protein -
C2L64_RS46740 520550..520777 + 228 WP_103154105.1 hypothetical protein -
C2L64_RS46745 520851..521876 + 1026 WP_103154106.1 IS30 family transposase -
C2L64_RS46750 521944..522597 + 654 WP_103154107.1 hypothetical protein -
C2L64_RS46755 522880..523143 + 264 WP_103154108.1 hypothetical protein -
C2L64_RS46760 523256..523963 - 708 Protein_472 IS6 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 520851..521876 1025


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

mRNA interferase PemK-like

(4-104)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 8990.17 Da        Isoelectric Point: 4.4805

>T93327 WP_103154102.1 NZ_CP026108:519332-519580 [Paraburkholderia hospita]
MKTTIRRMGNSQGVLIPKPVLAQLGLENEVEMEVENDAIVLRRPRHKARDGWAEASKALAESGDDALVMGEFGNADDAEL
AW

Download         Length: 249 bp

>T93327 NZ_CP026108:519332-519580 [Paraburkholderia hospita]
ATGAAAACAACGATTCGCAGGATGGGTAATTCGCAGGGCGTGCTGATTCCAAAGCCCGTCCTCGCGCAGTTGGGACTGGA
GAACGAAGTGGAAATGGAAGTTGAAAACGACGCGATTGTGCTGCGTCGCCCCCGCCATAAGGCTCGCGACGGTTGGGCTG
AGGCGAGCAAGGCGCTTGCTGAGAGCGGTGACGACGCGCTGGTGATGGGTGAGTTTGGCAACGCCGACGATGCGGAGCTT
GCATGGTAG

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11926.22 Da        Isoelectric Point: 10.5567

>AT93327 WP_103154103.1 NZ_CP026108:519574-519894 [Paraburkholderia hospita]
MVVRGEVWLVALDPTLGSEIQKTRPCVVVSPPEMHDHLRTVIVAPMTSKGRPAPFRIPVTFKRKQGLILLDQIRAVDKVR
LVKKEGVIADKTMLDTLRTLQEVFAE

Download         Length: 321 bp

>AT93327 NZ_CP026108:519574-519894 [Paraburkholderia hospita]
ATGGTAGTGCGCGGCGAAGTCTGGCTCGTTGCGCTCGATCCGACGCTAGGTAGCGAGATTCAAAAGACGCGGCCATGTGT
CGTGGTATCGCCGCCGGAAATGCACGACCATCTGCGGACGGTCATCGTCGCGCCGATGACTTCCAAGGGCCGCCCTGCGC
CGTTTCGCATACCCGTGACGTTCAAACGGAAACAGGGGTTGATCCTGCTGGATCAGATTCGCGCGGTAGACAAGGTGCGG
CTGGTAAAGAAAGAAGGCGTGATTGCCGATAAGACGATGTTGGACACCCTGCGTACCTTGCAGGAAGTGTTCGCGGAATA
G

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References