Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 70886..71511 Replicon chromosome
Accession NZ_CP026106
Organism Paraburkholderia hospita strain DSM 17164

Toxin (Protein)


Gene name mazF Uniprot ID A0A244DM89
Locus tag C2L64_RS18680 Protein ID WP_007583020.1
Coordinates 71167..71511 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A244DMF0
Locus tag C2L64_RS18675 Protein ID WP_007583018.1
Coordinates 70886..71158 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2L64_RS18650 67342..68502 + 1161 WP_007583008.1 DUF1501 domain-containing protein -
C2L64_RS18655 68578..68802 + 225 WP_039900693.1 YXWGXW repeat-containing protein -
C2L64_RS18660 68941..69426 + 486 WP_007583012.1 VOC family protein -
C2L64_RS18665 69520..69996 + 477 WP_007583014.1 VOC family protein -
C2L64_RS18670 70104..70628 + 525 WP_039900694.1 GNAT family N-acetyltransferase -
C2L64_RS18675 70886..71158 + 273 WP_007583018.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
C2L64_RS18680 71167..71511 + 345 WP_007583020.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
C2L64_RS18685 71525..72244 - 720 WP_007583022.1 GNAT family N-acetyltransferase -
C2L64_RS18690 72462..73676 + 1215 WP_007583023.1 DUF2252 domain-containing protein -
C2L64_RS18695 73925..74251 + 327 WP_007583025.1 hypothetical protein -
C2L64_RS18700 74432..75016 + 585 WP_007583028.1 flavin reductase family protein -
C2L64_RS18705 75042..75887 - 846 WP_007583030.1 AraC family transcriptional regulator -
C2L64_RS18710 75978..76337 - 360 WP_007583032.1 nuclear transport factor 2 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(9-111)

Antitoxin

Antitoxin PemI-like

(5-80)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12742.76 Da        Isoelectric Point: 7.3242

>T93325 WP_007583020.1 NZ_CP026106:71167-71511 [Paraburkholderia hospita]
MKNGVPEIGDVWWMSLEPVVGHEQGGSYPRPVVVLSHHEHNGPAQRIVAVPCTSKIRGFSTEIPVSALSKPCVALIDQIT
TLDWVARRGEFREERIAQPELDAIRRSLKAFLMM

Download         Length: 345 bp

>T93325 NZ_CP026106:71167-71511 [Paraburkholderia hospita]
ATGAAGAACGGCGTTCCCGAAATCGGCGATGTGTGGTGGATGAGTCTCGAACCCGTGGTCGGGCACGAGCAGGGCGGCAG
TTATCCTCGGCCCGTGGTGGTGTTGTCGCACCACGAGCACAACGGTCCGGCACAGCGCATTGTCGCCGTGCCGTGCACGT
CGAAGATACGCGGTTTTTCGACGGAGATTCCCGTCTCCGCGTTGTCAAAGCCGTGCGTCGCGCTGATCGACCAGATCACC
ACGCTCGACTGGGTGGCGCGGCGCGGTGAATTCAGGGAAGAGCGGATCGCGCAGCCCGAACTGGATGCGATCCGCCGCAG
TTTGAAAGCATTCCTGATGATGTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9963.06 Da        Isoelectric Point: 4.1606

>AT93325 WP_007583018.1 NZ_CP026106:70886-71158 [Paraburkholderia hospita]
MAIQTIKRWGNSLAVRIPASLAEELHLREDQEVDMVVADGALVATPAIRTFNWDEYREQLAARPGDVHPTIDHGVAVGSE
LADPTDQDDW

Download         Length: 273 bp

>AT93325 NZ_CP026106:70886-71158 [Paraburkholderia hospita]
ATGGCTATTCAGACAATCAAGCGGTGGGGCAACAGTCTTGCGGTGCGCATTCCCGCAAGCCTGGCGGAGGAACTGCACCT
GCGCGAAGATCAGGAAGTCGACATGGTGGTAGCGGATGGAGCGCTCGTCGCAACGCCCGCCATCAGGACGTTCAATTGGG
ACGAGTATCGCGAGCAACTCGCGGCGCGGCCCGGCGACGTGCATCCGACCATCGATCATGGCGTGGCTGTGGGTTCCGAA
CTTGCCGATCCAACGGACCAGGACGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A244DM89

Antitoxin

Source ID Structure
AlphaFold DB A0A244DMF0

References